Abstract
Staphylococcus aureus persistently colonizes about 20 % of the population and is intermittently associated with the remainder. The organism can cause superficial skin infections and life-threatening invasive diseases. The surface of the bacterial cell displays a variety of proteins that are covalently anchored to peptidoglycan. They perform many functions including adhesion to host cells and tissues, invasion of non-phagocytic cells, and evasion of innate immune responses. The proteins have been categorized into distinct classes based on structural and functional analysis. Many surface proteins are multifunctional. Cell wall-anchored proteins perform essential functions supporting survival and proliferation during the commensal state and during invasive infections. The ability of cell wall-anchored proteins to bind to desquamated epithelial cells is important during colonization, and the binding to fibrinogen is of particular significance in pathogenesis.
Original language | English |
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Pages (from-to) | 95-120 |
Number of pages | 26 |
Journal | Current Topics in Microbiology and Immunology |
Volume | 409 |
DOIs | |
Publication status | Published - 15 Dec 2015 |
Keywords
- Bacterial Adhesion
- Bacterial Proteins
- Cell Wall
- Membrane Proteins
- Staphylococcus aureus