Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions

Joan Geoghegan, Timothy J Foster

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Staphylococcus aureus persistently colonizes about 20 % of the population and is intermittently associated with the remainder. The organism can cause superficial skin infections and life-threatening invasive diseases. The surface of the bacterial cell displays a variety of proteins that are covalently anchored to peptidoglycan. They perform many functions including adhesion to host cells and tissues, invasion of non-phagocytic cells, and evasion of innate immune responses. The proteins have been categorized into distinct classes based on structural and functional analysis. Many surface proteins are multifunctional. Cell wall-anchored proteins perform essential functions supporting survival and proliferation during the commensal state and during invasive infections. The ability of cell wall-anchored proteins to bind to desquamated epithelial cells is important during colonization, and the binding to fibrinogen is of particular significance in pathogenesis.

Original languageEnglish
Pages (from-to)95-120
Number of pages26
JournalCurrent Topics in Microbiology and Immunology
Publication statusPublished - 15 Dec 2015


  • Bacterial Adhesion
  • Bacterial Proteins
  • Cell Wall
  • Membrane Proteins
  • Staphylococcus aureus


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