Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched

A Hidalgo, P Ingham

Research output: Contribution to journalArticlepeer-review

147 Citations (Scopus)

Abstract

Intrasegmental patterning in the Drosophila embryo requires the activity of the segment polarity genes. The acquisition of positional information by cells during embryogenesis is reflected in the dynamic patterns of expression of several of these genes. In the case of patched, early ubiquitous expression is followed by its repression in the anterior portion of each parasegment; subsequently each broad band of expression splits into two narrow stripes. In this study we analyse the contribution of other segment polarity gene functions to the evolution of this pattern; we find that the first step in patched regulation is under the control of engrailed whereas the second requires the activity of both cubitus interruptusD and patched itself. Furthermore, the products of engrailed, wingless and hedgehog are essential for maintaining the normal pattern of expression of patched.

Original languageEnglish
Pages (from-to)291-301
Number of pages11
JournalDevelopment (Cambridge)
Volume110
Issue number1
Publication statusPublished - Sep 1990

Keywords

  • Animals
  • Cell Communication
  • Drosophila
  • Epidermis
  • Gene Expression Regulation
  • Nucleic Acid Hybridization
  • Transcription, Genetic
  • Journal Article
  • Research Support, Non-U.S. Gov't

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