Cell mechanics in biomedical cavitation

Qian Wang, Kawa Manmi, Kuo-Kang Liu

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)
292 Downloads (Pure)

Abstract

Studies on the deformation behaviours of cellular entities, such as coated microbubbles and liposomes subject to a cavitation flow, become increasingly important for the advancement of ultrasonic imaging and drug delivery. Numerical simulations for bubble dynamics of ultrasound contrast agents based on the boundary integral method are presented in this work. The effects of the encapsulating shell are estimated by adapting Hoff's model used for thin-shell contrast agents. The viscosity effects are estimated by including the normal viscous stress in the boundary condition. In parallel, mechanical models of cell membranes and liposomes as well as state-of-the-art techniques for quantitative measurement of viscoelasticity for a single cell or coated microbubbles are reviewed. The future developments regarding modelling and measurement of the material properties of the cellular entities for cutting-edge biomedical applications are also discussed.
Original languageEnglish
JournalInterface Focus
Early online date21 Aug 2015
DOIs
Publication statusPublished - Oct 2015

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