Abstract
Gammaherpesviruses are agents which have evolved to persist within the lymphoid system and many have oncogenic potential; studying gammaherpesvirus infections therefore has the potential to reveal much about the workings of the immune system and the control over viral oncogenesis. The lymphocryptovirus Epstein-Barr virus (EBV) and the rhadinovirus Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8) are the two human gammaherpesviruses. Analysis of the T cell response to EBV has guided understanding of immunity to infection and disease caused by this virus, as well as directed the development of vaccination and therapeutic interventions in EBV-associated disease. Less is known about the T cell response to KSHV and its exact role in controlling virus infection and disease. Here we discuss the CD8+ T cell response to these two gammaherpesviruses.
| Original language | English |
|---|---|
| Pages (from-to) | 416-22 |
| Number of pages | 7 |
| Journal | Seminars in Cancer Biology |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Dec 2008 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Epstein-Barr virus
- Cellular immunology
- Kaposi's sarcoma-associated herpesvirus
- CD8 T cell
Fingerprint
Dive into the research topics of 'CD8+ T cell immunity to Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.'. Together they form a unique fingerprint.Projects
- 1 Finished
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Immunity to Gamma-Herpesviruses
Hislop, A. (Principal Investigator)
1/04/07 → 30/09/10
Project: Research Councils
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