CD8+ T cell immunity to Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.

Andrew Hislop; S Sabbah

doi:10.1016/j.semcancer.2008.10.005

CD8+ T cell immunity to Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.

Andrew Hislop, S Sabbah

Cancer and Genomic Sciences

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

Gammaherpesviruses are agents which have evolved to persist within the lymphoid system and many have oncogenic potential; studying gammaherpesvirus infections therefore has the potential to reveal much about the workings of the immune system and the control over viral oncogenesis. The lymphocryptovirus Epstein-Barr virus (EBV) and the rhadinovirus Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8) are the two human gammaherpesviruses. Analysis of the T cell response to EBV has guided understanding of immunity to infection and disease caused by this virus, as well as directed the development of vaccination and therapeutic interventions in EBV-associated disease. Less is known about the T cell response to KSHV and its exact role in controlling virus infection and disease. Here we discuss the CD8+ T cell response to these two gammaherpesviruses.

Original language	English
Pages (from-to)	416-22
Number of pages	7
Journal	Seminars in Cancer Biology
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/j.semcancer.2008.10.005
Publication status	Published - 1 Dec 2008

Keywords

Epstein-Barr virus
Cellular immunology
Kaposi's sarcoma-associated herpesvirus
CD8 T cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcancer.2008.10.005

Immunity to Gamma-Herpesviruses
Hislop, A. (Principal Investigator)
Medical Research Council
1/04/07 → 30/09/10
Project: Research Councils

Cite this

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title = "CD8+ T cell immunity to Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.",

abstract = "Gammaherpesviruses are agents which have evolved to persist within the lymphoid system and many have oncogenic potential; studying gammaherpesvirus infections therefore has the potential to reveal much about the workings of the immune system and the control over viral oncogenesis. The lymphocryptovirus Epstein-Barr virus (EBV) and the rhadinovirus Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8) are the two human gammaherpesviruses. Analysis of the T cell response to EBV has guided understanding of immunity to infection and disease caused by this virus, as well as directed the development of vaccination and therapeutic interventions in EBV-associated disease. Less is known about the T cell response to KSHV and its exact role in controlling virus infection and disease. Here we discuss the CD8+ T cell response to these two gammaherpesviruses.",

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T1 - CD8+ T cell immunity to Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.

AU - Hislop, Andrew

AU - Sabbah, S

PY - 2008/12/1

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N2 - Gammaherpesviruses are agents which have evolved to persist within the lymphoid system and many have oncogenic potential; studying gammaherpesvirus infections therefore has the potential to reveal much about the workings of the immune system and the control over viral oncogenesis. The lymphocryptovirus Epstein-Barr virus (EBV) and the rhadinovirus Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8) are the two human gammaherpesviruses. Analysis of the T cell response to EBV has guided understanding of immunity to infection and disease caused by this virus, as well as directed the development of vaccination and therapeutic interventions in EBV-associated disease. Less is known about the T cell response to KSHV and its exact role in controlling virus infection and disease. Here we discuss the CD8+ T cell response to these two gammaherpesviruses.

AB - Gammaherpesviruses are agents which have evolved to persist within the lymphoid system and many have oncogenic potential; studying gammaherpesvirus infections therefore has the potential to reveal much about the workings of the immune system and the control over viral oncogenesis. The lymphocryptovirus Epstein-Barr virus (EBV) and the rhadinovirus Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8) are the two human gammaherpesviruses. Analysis of the T cell response to EBV has guided understanding of immunity to infection and disease caused by this virus, as well as directed the development of vaccination and therapeutic interventions in EBV-associated disease. Less is known about the T cell response to KSHV and its exact role in controlling virus infection and disease. Here we discuss the CD8+ T cell response to these two gammaherpesviruses.

KW - Epstein-Barr virus

KW - Cellular immunology

KW - Kaposi's sarcoma-associated herpesvirus

KW - CD8 T cell

U2 - 10.1016/j.semcancer.2008.10.005

DO - 10.1016/j.semcancer.2008.10.005

M3 - Article

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VL - 18

SP - 416

EP - 422

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

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ER -

CD8+ T cell immunity to Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.

Abstract

Keywords

UN SDGs

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Projects

Immunity to Gamma-Herpesviruses

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