CD4+ T cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain epitopes

Chi Tsang, X Lin, Nancy Gudgeon, Graham Taylor, Hui Jia, P Hui, ATC Chan, CK Lin, Alan Rickinson

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21 Citations (Scopus)
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Abstract

Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes, presented by HLA alleles in Chinese people, the group at highest risk for NPC. We analyzed the CD4\(^+\) T-cell responses to EBNA1 in 78 healthy Chinese donors and found marked focusing on a small number of epitopes in the EBNA1 C-terminal region, including a DP5- restricted epitope that was recognized by almost half of the donors tested and elicited responses able to recognize EBNA1-expressing, DP5-positive target cells.
Original languageEnglish
Pages (from-to)8263-8266
Number of pages4
JournalJournal of virology
Volume80
DOIs
Publication statusPublished - 15 Aug 2006

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