CD4+ CD28 null T cells in coronary artery disease: when helpers become killers

Ingrid Dumitriu; Ernesto Trallero Araguás; Christina Baboonian; Juan Carlos Kaski

doi:10.1093/cvr/cvn248

CD4+ CD28 null T cells in coronary artery disease: when helpers become killers

Ingrid Dumitriu, Ernesto Trallero Araguás, Christina Baboonian, Juan Carlos Kaski

Cardiovascular Sciences

Research output: Contribution to journal › Review article › peer-review

92 Citations (Scopus)

Abstract

The crucial role of T cells in atherosclerosis and coronary artery disease (CAD) has been highlighted by recent observations. Helper CD4(+) T cells can both aggravate or attenuate the atherogenic process and the development of CAD. CD4(+)CD28(null) T cells are an unusual subset of helper cells which expand and have deleterious effects in CAD. In this review, we discuss the current issues on the generation of CD4(+)CD28(null) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. The possible effects of the present day therapies for CAD on the CD4(+)CD28(null) T cells are also explored. Targeting the CD4(+)CD28(null) T cell subset in CAD could provide novel therapeutic strategies to prevent acute life-threatening coronary events.

Original language	English
Pages (from-to)	11-9
Number of pages	9
Journal	Cardiovascular Research
Volume	81
Issue number	1
DOIs	https://doi.org/10.1093/cvr/cvn248
Publication status	Published - 1 Jan 2009

Keywords

Animals
Autoimmune Diseases/pathology
CD28 Antigens/genetics
Coronary Artery Disease/drug therapy
Coronary Vessels/pathology
Disease Models, Animal
Humans
T-Lymphocytes, Helper-Inducer/immunology
Thrombosis/pathology

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10.1093/cvr/cvn248

Cite this

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title = "CD4+ CD28 null T cells in coronary artery disease: when helpers become killers",

abstract = "The crucial role of T cells in atherosclerosis and coronary artery disease (CAD) has been highlighted by recent observations. Helper CD4(+) T cells can both aggravate or attenuate the atherogenic process and the development of CAD. CD4(+)CD28(null) T cells are an unusual subset of helper cells which expand and have deleterious effects in CAD. In this review, we discuss the current issues on the generation of CD4(+)CD28(null) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. The possible effects of the present day therapies for CAD on the CD4(+)CD28(null) T cells are also explored. Targeting the CD4(+)CD28(null) T cell subset in CAD could provide novel therapeutic strategies to prevent acute life-threatening coronary events.",

keywords = "Animals, Autoimmune Diseases/pathology, CD28 Antigens/genetics, Coronary Artery Disease/drug therapy, Coronary Vessels/pathology, Disease Models, Animal, Humans, T-Lymphocytes, Helper-Inducer/immunology, Thrombosis/pathology",

author = "Ingrid Dumitriu and Aragu{\'a}s, {Ernesto Trallero} and Christina Baboonian and Kaski, {Juan Carlos}",

year = "2009",

month = jan,

day = "1",

doi = "10.1093/cvr/cvn248",

language = "English",

volume = "81",

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journal = "Cardiovascular Research",

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T1 - CD4+ CD28 null T cells in coronary artery disease

T2 - when helpers become killers

AU - Dumitriu, Ingrid

AU - Araguás, Ernesto Trallero

AU - Baboonian, Christina

AU - Kaski, Juan Carlos

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The crucial role of T cells in atherosclerosis and coronary artery disease (CAD) has been highlighted by recent observations. Helper CD4(+) T cells can both aggravate or attenuate the atherogenic process and the development of CAD. CD4(+)CD28(null) T cells are an unusual subset of helper cells which expand and have deleterious effects in CAD. In this review, we discuss the current issues on the generation of CD4(+)CD28(null) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. The possible effects of the present day therapies for CAD on the CD4(+)CD28(null) T cells are also explored. Targeting the CD4(+)CD28(null) T cell subset in CAD could provide novel therapeutic strategies to prevent acute life-threatening coronary events.

AB - The crucial role of T cells in atherosclerosis and coronary artery disease (CAD) has been highlighted by recent observations. Helper CD4(+) T cells can both aggravate or attenuate the atherogenic process and the development of CAD. CD4(+)CD28(null) T cells are an unusual subset of helper cells which expand and have deleterious effects in CAD. In this review, we discuss the current issues on the generation of CD4(+)CD28(null) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. The possible effects of the present day therapies for CAD on the CD4(+)CD28(null) T cells are also explored. Targeting the CD4(+)CD28(null) T cell subset in CAD could provide novel therapeutic strategies to prevent acute life-threatening coronary events.

KW - Animals

KW - Autoimmune Diseases/pathology

KW - CD28 Antigens/genetics

KW - Coronary Artery Disease/drug therapy

KW - Coronary Vessels/pathology

KW - Disease Models, Animal

KW - Humans

KW - T-Lymphocytes, Helper-Inducer/immunology

KW - Thrombosis/pathology

U2 - 10.1093/cvr/cvn248

DO - 10.1093/cvr/cvn248

M3 - Review article

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SN - 0008-6363

VL - 81

SP - 11

EP - 19

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 1

ER -

CD4+ CD28 null T cells in coronary artery disease: when helpers become killers

Abstract

Keywords

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