CD4+ CD28 null T cells in coronary artery disease: when helpers become killers

Ingrid Dumitriu, Ernesto Trallero Araguás, Christina Baboonian, Juan Carlos Kaski

Research output: Contribution to journalReview articlepeer-review

92 Citations (Scopus)


The crucial role of T cells in atherosclerosis and coronary artery disease (CAD) has been highlighted by recent observations. Helper CD4(+) T cells can both aggravate or attenuate the atherogenic process and the development of CAD. CD4(+)CD28(null) T cells are an unusual subset of helper cells which expand and have deleterious effects in CAD. In this review, we discuss the current issues on the generation of CD4(+)CD28(null) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. The possible effects of the present day therapies for CAD on the CD4(+)CD28(null) T cells are also explored. Targeting the CD4(+)CD28(null) T cell subset in CAD could provide novel therapeutic strategies to prevent acute life-threatening coronary events.

Original languageEnglish
Pages (from-to)11-9
Number of pages9
JournalCardiovascular Research
Issue number1
Publication statusPublished - 1 Jan 2009


  • Animals
  • Autoimmune Diseases/pathology
  • CD28 Antigens/genetics
  • Coronary Artery Disease/drug therapy
  • Coronary Vessels/pathology
  • Disease Models, Animal
  • Humans
  • T-Lymphocytes, Helper-Inducer/immunology
  • Thrombosis/pathology


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