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Abstract
Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103+CD11b+ (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103+CD11b- (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α4β7+, suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.
Original language | English |
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Pages (from-to) | 681-692 |
Number of pages | 12 |
Journal | Mucosal immunology |
Volume | 11 |
Issue number | 3 |
Early online date | 20 Dec 2017 |
DOIs | |
Publication status | Published - May 2018 |
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Dive into the research topics of 'CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin'. Together they form a unique fingerprint.Projects
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How does systemic flagellin immunization induce mucosal lgA?
Cunningham, A. (Principal Investigator) & Toellner, K. (Co-Investigator)
Biotechnology & Biological Sciences Research Council
1/02/14 → 31/01/18
Project: Research Councils