Cardiovascular health and mortality in Cushing’s disease

Amy Coulden, Ross Hamblin, John Wass, Niki Karavitaki

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Exposure to cortisol excess in Cushing’s disease (CD) results in increased cardiovascular morbidity and reduces survival, with cardiovascular disease being a leading cause of death. At diagnosis, a significant number of patients have adverse cardiovascular profiles (e.g., obesity, diabetes or impaired glucose tolerance, dyslipidemia, hypertension, cardiac abnormalities and vascular disease). Remission of hypercortisolemia reduces but does not completely eliminate the cardiovascular complications; hazard ratios for myocardial infarction and stroke are high during long-term monitoring, highlighting the long-lasting effects of hypercortisolism and the importance of the timely diagnosis and successful management of this condition. Data on mortality of patients in remission are not consistent but in a multicenter study, an increased all-cause and circulatory mortality in patients with CD in remission for at least 10 years has been demonstrated. Cardiovascular morbidity requires particular focus and effective management during the care of patients with CD, from their presentation until long-term follow up.
Original languageEnglish
Pages (from-to)750-753
Issue number5
Early online date22 Jul 2022
Publication statusE-pub ahead of print - 22 Jul 2022

Bibliographical note

Funding Information:
RH has received a conference grant from Recordati Rare Diseases UK Ltd. NK has received honoraria from Pfizer, Ipsen, HRA Pharma and Recordati Rare Diseases for lectures, research funding from Pfizer, Ipsen and Shire and has served as a member in Scientific Advisory Boards for Pfizer, Ipsen, Recordati Rare Diseases.

Publisher Copyright:
© 2022, Crown.


  • Cushing’s Disease
  • Hypercortisolemia
  • Cardiovascular Health
  • Mortality


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