Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF

John F. O’Sullivan; Mengbo Li; Yen Chin Koay; Xiao Suo Wang; Giovanni Guglielmi; Francine Z. Marques; Shane Nanayakkara; Justin Mariani; Eugene Slaughter; David M. Kaye

doi:10.1016/j.jacbts.2023.11.006

Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF

John F. O’Sullivan^*, Mengbo Li, Yen Chin Koay, Xiao Suo Wang, Giovanni Guglielmi, Francine Z. Marques, Shane Nanayakkara, Justin Mariani, Eugene Slaughter, David M. Kaye^*

^*Corresponding author for this work

Mathematics

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Abstract

We conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.

Original language	English
Journal	JACC: Basic to Translational Science
Early online date	31 Jan 2024
DOIs	https://doi.org/10.1016/j.jacbts.2023.11.006
Publication status	E-pub ahead of print - 31 Jan 2024

Bibliographical note

Funding Support and Author Disclosures:
Samples were collected with support of a National Health & Medical Research Council (NHMRC) of Australia Project Grant (GNT1159721) to Drs Marques and Kaye. Dr Kaye is the recipient of an NHMRC Investigator Grant (Level 3). Dr O’Sullivan is supported by an National Heart Foundation (NHF) Future Leader Fellowship (Level 2) and an New South Wales early to mid career (NSW EMCR) award. Dr Marques is supported by a Senior Medical Research Fellowship from the Sylvia and Charles Viertel Charitable Foundation, a National Heart Foundation Future Leader Fellowship (105663), and NHMRC Emerging Leader Grant (GNT2017382). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Keywords

cardiac energetics
heart failure with preserved ejection fraction
invasive hemodynamics
lipids

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10.1016/j.jacbts.2023.11.006Licence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

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Cite this

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title = "Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF",

abstract = "We conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.",

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note = "Funding Support and Author Disclosures: Samples were collected with support of a National Health & Medical Research Council (NHMRC) of Australia Project Grant (GNT1159721) to Drs Marques and Kaye. Dr Kaye is the recipient of an NHMRC Investigator Grant (Level 3). Dr O{\textquoteright}Sullivan is supported by an National Heart Foundation (NHF) Future Leader Fellowship (Level 2) and an New South Wales early to mid career (NSW EMCR) award. Dr Marques is supported by a Senior Medical Research Fellowship from the Sylvia and Charles Viertel Charitable Foundation, a National Heart Foundation Future Leader Fellowship (105663), and NHMRC Emerging Leader Grant (GNT2017382). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.",

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AU - O’Sullivan, John F.

AU - Li, Mengbo

AU - Koay, Yen Chin

AU - Wang, Xiao Suo

AU - Guglielmi, Giovanni

AU - Marques, Francine Z.

AU - Nanayakkara, Shane

AU - Mariani, Justin

AU - Slaughter, Eugene

AU - Kaye, David M.

N1 - Funding Support and Author Disclosures: Samples were collected with support of a National Health & Medical Research Council (NHMRC) of Australia Project Grant (GNT1159721) to Drs Marques and Kaye. Dr Kaye is the recipient of an NHMRC Investigator Grant (Level 3). Dr O’Sullivan is supported by an National Heart Foundation (NHF) Future Leader Fellowship (Level 2) and an New South Wales early to mid career (NSW EMCR) award. Dr Marques is supported by a Senior Medical Research Fellowship from the Sylvia and Charles Viertel Charitable Foundation, a National Heart Foundation Future Leader Fellowship (105663), and NHMRC Emerging Leader Grant (GNT2017382). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

PY - 2024/1/31

Y1 - 2024/1/31

N2 - We conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.

AB - We conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.

KW - cardiac energetics

KW - heart failure with preserved ejection fraction

KW - invasive hemodynamics

KW - lipids

U2 - 10.1016/j.jacbts.2023.11.006

DO - 10.1016/j.jacbts.2023.11.006

M3 - Article

SN - 2452-302X

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

ER -

Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF

Abstract

Bibliographical note

Keywords

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