Cardiac optical mapping – state-of-the-art and future challenges

Christopher O'Shea; S. Nashitha Kabir; Andrew P. Holmes; Ming Lei; Larissa Fabritz; Kashif Rajpoot; Davor Pavlovic

doi:10.1016/j.biocel.2020.105804

Cardiac optical mapping – state-of-the-art and future challenges

Christopher O'Shea, S. Nashitha Kabir, Andrew P. Holmes, Ming Lei, Larissa Fabritz, Kashif Rajpoot, Davor Pavlovic^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

1 Citation (Scopus)

383 Downloads (Pure)

Abstract

Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has therefore become an invaluable tool in cardiac electrophysiological research to map the propagation of heterogeneous electrical signals across the myocardium. In this review, we introduce the principles behind cardiac optical mapping and discuss some of the challenges and state of the art in the field. Key advancements discussed include newly developed fluorescent indicators, tools for the analysis of complex datasets, panoramic imaging systems and technical and computational approaches to realise optical mapping in freely beating hearts.

Original language	English
Article number	105804
Journal	International Journal of Biochemistry and Cell Biology
Volume	126
Early online date	15 Jul 2020
DOIs	https://doi.org/10.1016/j.biocel.2020.105804
Publication status	Published - Sept 2020

Keywords

Action potential
Arrhythmia
Calcium transient
Cardiac optical mapping
Electrophysiology
Fluorescent imaging

ASJC Scopus subject areas

Biochemistry
Cell Biology

Access to Document

10.1016/j.biocel.2020.105804Licence: Creative Commons: Attribution (CC BY)

osheac2020cardiacFinal published version, 700 KBLicence: Creative Commons: Attribution (CC BY)

https://doi.org/10.1016/j.biocel.2020.105804Licence: Creative Commons: Attribution (CC BY)

Cardiotonic steroids in patients with atrial fibrillation and heart failure: Quantification, functional effects and personalisation of digoxin therapy
Arlt, W. (Co-Investigator), Pavlovic, D. (Principal Investigator), Taylor, A. (Co-Investigator), Kotecha, D. (Co-Investigator) & Kirchhof, P. (Co-Investigator)
British Heart Foundation
1/06/18 → 30/05/21
Project: Research

Cite this

@article{cb5aaea795764f239007458336688612,

title = "Cardiac optical mapping – state-of-the-art and future challenges",

abstract = "Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has therefore become an invaluable tool in cardiac electrophysiological research to map the propagation of heterogeneous electrical signals across the myocardium. In this review, we introduce the principles behind cardiac optical mapping and discuss some of the challenges and state of the art in the field. Key advancements discussed include newly developed fluorescent indicators, tools for the analysis of complex datasets, panoramic imaging systems and technical and computational approaches to realise optical mapping in freely beating hearts.",

keywords = "Action potential, Arrhythmia, Calcium transient, Cardiac optical mapping, Electrophysiology, Fluorescent imaging",

author = "Christopher O'Shea and Kabir, {S. Nashitha} and Holmes, {Andrew P.} and Ming Lei and Larissa Fabritz and Kashif Rajpoot and Davor Pavlovic",

year = "2020",

month = sep,

doi = "10.1016/j.biocel.2020.105804",

language = "English",

volume = "126",

journal = "International Journal of Biochemistry and Cell Biology",

issn = "1357-2725",

publisher = "Elsevier",

}

TY - JOUR

T1 - Cardiac optical mapping – state-of-the-art and future challenges

AU - O'Shea, Christopher

AU - Kabir, S. Nashitha

AU - Holmes, Andrew P.

AU - Lei, Ming

AU - Fabritz, Larissa

AU - Rajpoot, Kashif

AU - Pavlovic, Davor

PY - 2020/9

Y1 - 2020/9

N2 - Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has therefore become an invaluable tool in cardiac electrophysiological research to map the propagation of heterogeneous electrical signals across the myocardium. In this review, we introduce the principles behind cardiac optical mapping and discuss some of the challenges and state of the art in the field. Key advancements discussed include newly developed fluorescent indicators, tools for the analysis of complex datasets, panoramic imaging systems and technical and computational approaches to realise optical mapping in freely beating hearts.

AB - Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has therefore become an invaluable tool in cardiac electrophysiological research to map the propagation of heterogeneous electrical signals across the myocardium. In this review, we introduce the principles behind cardiac optical mapping and discuss some of the challenges and state of the art in the field. Key advancements discussed include newly developed fluorescent indicators, tools for the analysis of complex datasets, panoramic imaging systems and technical and computational approaches to realise optical mapping in freely beating hearts.

KW - Action potential

KW - Arrhythmia

KW - Calcium transient

KW - Cardiac optical mapping

KW - Electrophysiology

KW - Fluorescent imaging

UR - http://www.scopus.com/inward/record.url?scp=85088124182&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2020.105804

DO - 10.1016/j.biocel.2020.105804

M3 - Short survey

C2 - 32681973

AN - SCOPUS:85088124182

SN - 1357-2725

VL - 126

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

M1 - 105804

ER -

Cardiac optical mapping – state-of-the-art and future challenges

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Projects

Cardiotonic steroids in patients with atrial fibrillation and heart failure: Quantification, functional effects and personalisation of digoxin therapy

Cite this