Cardiac Diseases Following Childhood Cancer Treatment: Cohort Study

Nadia Haddy; Stéphanie Diallo; Chiraz El-Fayech; Boris Schwartz; François Pein; Michael Hawkins; Cristina Veres; Odile Oberlin; Catherine Guibout; Hélène Pacquement; Martine Munzer; Tan Dat N'Guyen; Pierre-Yves Bondiau; Delphine Berchery; Anne Laprie; Pierre-Yves Scarabin; Xavier Jouven; André Bridier; Serge Koscielny; Eric Deutsch; Ibrahima Diallo; Florent de Vathaire

doi:10.1161/CIRCULATIONAHA.115.016686

Cardiac Diseases Following Childhood Cancer Treatment: Cohort Study

Nadia Haddy, Stéphanie Diallo, Chiraz El-Fayech, Boris Schwartz, François Pein, Michael Hawkins, Cristina Veres, Odile Oberlin, Catherine Guibout, Hélène Pacquement, Martine Munzer, Tan Dat N'Guyen, Pierre-Yves Bondiau, Delphine Berchery, Anne Laprie, Pierre-Yves Scarabin, Xavier Jouven, André Bridier, Serge Koscielny, Eric DeutschIbrahima Diallo, Florent de Vathaire

Applied Health Research

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

BACKGROUND: Cardiac disease (CD) is one of the major side effects of childhood cancer therapy, but until now little has been known about the relationship between the heart radiation dose (HRD) received during childhood and the risk of CD.

METHODS AND RESULTS: The cohort comprised 3162 5-year survivors of childhood cancer. Chemotherapy information was collected and HRD was estimated. There were 347 CDs in 234 patients, 156 of them were rated grade ≥3. Cox and Poisson regression models were used. The cumulative incidence of any type of CD at 40 years of age was 11.0% (95% confidence interval [CI], 9.5-12.7) and 7·4% (95% CI, 6.2-8.9) when only the CDs of grade ≥3 were considered. In comparison with patients who received no anthracycline and either no radiotherapy or an HRD<0·1Gy, the risk was multiplied by 18·4 (95% CI, 7.1-48.0) in patients who had received anthracycline and no radiotherapy or a HRD <0.1Gy, by 60.4 (95% CI, 22.4-163.0) in those who had received no anthracycline and an HRD≥30Gy, and 61.5 (95% CI, 19.6-192.8) in those who had received both anthracycline and an HRD≥30Gy.

CONCLUSIONS: Survivors of childhood cancers treated with radiotherapy and anthracycline run a high dose-dependent risk of developing CD. CDs develop earlier in patients treated with anthracycline than in those treated without it.

Original language	English
Pages (from-to)	31-8
Number of pages	8
Journal	Circulation
Volume	133
Issue number	1
Early online date	20 Oct 2015
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.115.016686
Publication status	Published - 5 Jan 2016

Keywords

Adult
Anthracyclines
Antineoplastic Agents
Antineoplastic Protocols
Child
Child, Preschool
Cohort Studies
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Female
Heart Diseases
Humans
Male
Neoplasms
Risk Factors
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1161/CIRCULATIONAHA.115.016686

Cite this

Haddy, N., Diallo, S., El-Fayech, C., Schwartz, B., Pein, F., Hawkins, M., Veres, C., Oberlin, O., Guibout, C., Pacquement, H., Munzer, M., N'Guyen, T. D., Bondiau, P-Y., Berchery, D., Laprie, A., Scarabin, P-Y., Jouven, X., Bridier, A., Koscielny, S., ... de Vathaire, F. (2016). Cardiac Diseases Following Childhood Cancer Treatment: Cohort Study. Circulation, 133(1), 31-8. https://doi.org/10.1161/CIRCULATIONAHA.115.016686

@article{37e9a0e5df2443e985820100bde3fa1f,

title = "Cardiac Diseases Following Childhood Cancer Treatment: Cohort Study",

abstract = "BACKGROUND: Cardiac disease (CD) is one of the major side effects of childhood cancer therapy, but until now little has been known about the relationship between the heart radiation dose (HRD) received during childhood and the risk of CD.METHODS AND RESULTS: The cohort comprised 3162 5-year survivors of childhood cancer. Chemotherapy information was collected and HRD was estimated. There were 347 CDs in 234 patients, 156 of them were rated grade ≥3. Cox and Poisson regression models were used. The cumulative incidence of any type of CD at 40 years of age was 11.0% (95% confidence interval [CI], 9.5-12.7) and 7·4% (95% CI, 6.2-8.9) when only the CDs of grade ≥3 were considered. In comparison with patients who received no anthracycline and either no radiotherapy or an HRD<0·1Gy, the risk was multiplied by 18·4 (95% CI, 7.1-48.0) in patients who had received anthracycline and no radiotherapy or a HRD <0.1Gy, by 60.4 (95% CI, 22.4-163.0) in those who had received no anthracycline and an HRD≥30Gy, and 61.5 (95% CI, 19.6-192.8) in those who had received both anthracycline and an HRD≥30Gy.CONCLUSIONS: Survivors of childhood cancers treated with radiotherapy and anthracycline run a high dose-dependent risk of developing CD. CDs develop earlier in patients treated with anthracycline than in those treated without it.",

keywords = "Adult, Anthracyclines, Antineoplastic Agents, Antineoplastic Protocols, Child, Child, Preschool, Cohort Studies, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Female, Heart Diseases, Humans, Male, Neoplasms, Risk Factors, Journal Article, Research Support, Non-U.S. Gov't",

author = "Nadia Haddy and St{\'e}phanie Diallo and Chiraz El-Fayech and Boris Schwartz and Fran{\c c}ois Pein and Michael Hawkins and Cristina Veres and Odile Oberlin and Catherine Guibout and H{\'e}l{\`e}ne Pacquement and Martine Munzer and N'Guyen, {Tan Dat} and Pierre-Yves Bondiau and Delphine Berchery and Anne Laprie and Pierre-Yves Scarabin and Xavier Jouven and Andr{\'e} Bridier and Serge Koscielny and Eric Deutsch and Ibrahima Diallo and {de Vathaire}, Florent",

note = "{\textcopyright} 2015 American Heart Association, Inc.",

year = "2016",

month = jan,

day = "5",

doi = "10.1161/CIRCULATIONAHA.115.016686",

language = "English",

volume = "133",

pages = "31--8",

journal = "Circulation",

issn = "0009-7322",

publisher = "American Heart Association",

number = "1",

}

Haddy, N, Diallo, S, El-Fayech, C, Schwartz, B, Pein, F, Hawkins, M, Veres, C, Oberlin, O, Guibout, C, Pacquement, H, Munzer, M, N'Guyen, TD, Bondiau, P-Y, Berchery, D, Laprie, A, Scarabin, P-Y, Jouven, X, Bridier, A, Koscielny, S, Deutsch, E, Diallo, I & de Vathaire, F 2016, 'Cardiac Diseases Following Childhood Cancer Treatment: Cohort Study', Circulation, vol. 133, no. 1, pp. 31-8. https://doi.org/10.1161/CIRCULATIONAHA.115.016686

TY - JOUR

T1 - Cardiac Diseases Following Childhood Cancer Treatment

T2 - Cohort Study

AU - Haddy, Nadia

AU - Diallo, Stéphanie

AU - El-Fayech, Chiraz

AU - Schwartz, Boris

AU - Pein, François

AU - Hawkins, Michael

AU - Veres, Cristina

AU - Oberlin, Odile

AU - Guibout, Catherine

AU - Pacquement, Hélène

AU - Munzer, Martine

AU - N'Guyen, Tan Dat

AU - Bondiau, Pierre-Yves

AU - Berchery, Delphine

AU - Laprie, Anne

AU - Scarabin, Pierre-Yves

AU - Jouven, Xavier

AU - Bridier, André

AU - Koscielny, Serge

AU - Deutsch, Eric

AU - Diallo, Ibrahima

AU - de Vathaire, Florent

PY - 2016/1/5

Y1 - 2016/1/5

N2 - BACKGROUND: Cardiac disease (CD) is one of the major side effects of childhood cancer therapy, but until now little has been known about the relationship between the heart radiation dose (HRD) received during childhood and the risk of CD.METHODS AND RESULTS: The cohort comprised 3162 5-year survivors of childhood cancer. Chemotherapy information was collected and HRD was estimated. There were 347 CDs in 234 patients, 156 of them were rated grade ≥3. Cox and Poisson regression models were used. The cumulative incidence of any type of CD at 40 years of age was 11.0% (95% confidence interval [CI], 9.5-12.7) and 7·4% (95% CI, 6.2-8.9) when only the CDs of grade ≥3 were considered. In comparison with patients who received no anthracycline and either no radiotherapy or an HRD<0·1Gy, the risk was multiplied by 18·4 (95% CI, 7.1-48.0) in patients who had received anthracycline and no radiotherapy or a HRD <0.1Gy, by 60.4 (95% CI, 22.4-163.0) in those who had received no anthracycline and an HRD≥30Gy, and 61.5 (95% CI, 19.6-192.8) in those who had received both anthracycline and an HRD≥30Gy.CONCLUSIONS: Survivors of childhood cancers treated with radiotherapy and anthracycline run a high dose-dependent risk of developing CD. CDs develop earlier in patients treated with anthracycline than in those treated without it.

AB - BACKGROUND: Cardiac disease (CD) is one of the major side effects of childhood cancer therapy, but until now little has been known about the relationship between the heart radiation dose (HRD) received during childhood and the risk of CD.METHODS AND RESULTS: The cohort comprised 3162 5-year survivors of childhood cancer. Chemotherapy information was collected and HRD was estimated. There were 347 CDs in 234 patients, 156 of them were rated grade ≥3. Cox and Poisson regression models were used. The cumulative incidence of any type of CD at 40 years of age was 11.0% (95% confidence interval [CI], 9.5-12.7) and 7·4% (95% CI, 6.2-8.9) when only the CDs of grade ≥3 were considered. In comparison with patients who received no anthracycline and either no radiotherapy or an HRD<0·1Gy, the risk was multiplied by 18·4 (95% CI, 7.1-48.0) in patients who had received anthracycline and no radiotherapy or a HRD <0.1Gy, by 60.4 (95% CI, 22.4-163.0) in those who had received no anthracycline and an HRD≥30Gy, and 61.5 (95% CI, 19.6-192.8) in those who had received both anthracycline and an HRD≥30Gy.CONCLUSIONS: Survivors of childhood cancers treated with radiotherapy and anthracycline run a high dose-dependent risk of developing CD. CDs develop earlier in patients treated with anthracycline than in those treated without it.

KW - Adult

KW - Anthracyclines

KW - Antineoplastic Agents

KW - Antineoplastic Protocols

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Dose-Response Relationship, Drug

KW - Dose-Response Relationship, Radiation

KW - Female

KW - Heart Diseases

KW - Humans

KW - Male

KW - Neoplasms

KW - Risk Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1161/CIRCULATIONAHA.115.016686

DO - 10.1161/CIRCULATIONAHA.115.016686

M3 - Article

C2 - 26487757

SN - 0009-7322

VL - 133

SP - 31

EP - 38

JO - Circulation

JF - Circulation

IS - 1

ER -

Cardiac Diseases Following Childhood Cancer Treatment: Cohort Study

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this