Cardiac autonomic neuropathy in patients with diabetes mellitus: Current perspectives

Victoria L. Fisher, Abd A. Tahrani*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)
256 Downloads (Pure)


Cardiac autonomic neuropathy (CAN) is a common and often-underdiagnosed complication of diabetes mellitus (DM). CAN is associated with increased mortality, cardiovascular disease, chronic kidney disease, and morbidity in patients with DM, but despite these significant consequences CAN often remains undiagnosed for a prolonged period. This is commonly due to the disease being asymptomatic until the later stages, as well as a lack of easily available screening strategies. In this article, we review the latest developments in the epidemiology, pathogenesis, diagnosis, consequences, and treatments of CAN in patients with DM.

Original languageEnglish
Pages (from-to)419-434
Number of pages16
JournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Publication statusPublished - 6 Oct 2017


  • 30:15 ratio
  • Autonomic
  • Cardiovascular
  • Deep breathing
  • Ewing criteria
  • Ewing tests
  • Heart-rate variability
  • Hyperglycemia
  • Neuropathy
  • Orthostatic hypotension
  • Parasympathetic
  • Postural hypotension
  • Sympathetic
  • Valsalva ratio

ASJC Scopus subject areas

  • Internal Medicine
  • Pharmacology


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