Carbohydrate beverage ingestion and neutrophil degranulation responses following cycling to fatigue at 75% VO2max

NC Bishop, Andrew Blannin, NP Walsh, Michael Gleeson

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Carbohydrate (CHO) beverage ingestion appears to influence neutrophil functional responses to prolonged exercise of a fixed duration. The aim of this randomised study was to examine the effect of CHO (5 % w/v) beverage ingestion on lipopoly-saccharide (LPS)-stimulated neutrophil degranulation responses in nine recreationally active males who cycled at 75 % VO2 max until fatigue. On two separate occasions, subjects ingested either placebo (PLA) or CHO beverages before and at 15 min intervals during the exercise. Subjects exercised for 31% longer on the CHO trial compared with the PLA trial (P<0.05). At fatigue plasma glucose concentration was significantly lower on the PLA trial compared with the CHO trial (P<0.05). Plasma cortisol concentrations had increased similarly on both trials at this time. A marked neutrophilia was evident at fatigue and throughout the 4h recovery period, the magnitude of which was similar on both trials. At fatigue LPS-stimulated elastase release per neutrophil had fallen similarly on both trials compared with pre-exercise values (47% and 50% on the PLA and CHO trials, respectively). In conclusion, our results suggest that CHO beverage ingestion has negligible influence on the hormonal, circulating neutrophil and LPS-stimulated neutrophil degranulation responses when exercise is performed to fatigue.
Original languageEnglish
Pages (from-to)226-231
Number of pages6
JournalInternational Journal of Sports Medicine
Issue number3
Publication statusPublished - 1 Apr 2001


  • cortisol
  • carbohydrate
  • neutrophil
  • exercise


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