Can We Predict Stroke in Atrial Fibrillation?

Gregory Lip

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Stroke prevention with appropriate thromboprophylaxis still remains central to the management of atrial fibrillation (AF). Nonetheless, stroke risk in AF is not homogeneous, but despite stroke risk in AF being a continuum, prior stroke risk stratification schema have been used to artificially categorise patients into low, moderate and high risk stroke strata, so that the patients at highest risk can be identified for warfarin therapy. Data from recent large cohort studies show that by being more inclusive, rather than exclusive, of common stroke risk factors in the assessment of the risk for stroke and thromboembolism in AF patients, we can be so much better in assessing stroke risk, and in optimising thromboprophylaxis with the resultant reduction in stroke and mortality. Thus, there has been a recent paradigm shift towards getting better at identifying the truly low risk patients with AF who do not even need antithrombotic therapy, whilst those with one or more stroke risk factors can be treated with oral anticoagulation, whether as well-controlled warfarin or one or the new oral anticoagulant drugs. The new European guidelines on AF have evolved to deemphasise the artificial low/moderate/high risk strata (as they were not very predictive of thromboembolism, anyway) and stressed a risk factor based approach (within the CHA(2)DS(2)-VASc score) given that stroke risk is a continuum. Those categorised as 'low risk' using the CHA2DS2-VASc score are ' truly low risk' for thromboembolism, and the CHA2DS2-VASc score performs as good as-and possibly better-than the CHADS(2) score in predicting those at ' high risk'. Indeed, those patients with a CHA2DS2-VASc score =0 are ' truly low risk' so that no antithrombotic therapy is preferred, whilst in those with a CHA2DS2-VASc score of 1 or more, oral anticoagulation is recommended or preferred. Given that guidelines should be applicable for > 80% of the time, for > 80% of the patients, this stroke risk assessment approach covers the majority of the patients we commonly seen in everyday clinical practice, and considers the common stroke risk factors seen in these patients. The European guidelines also do stress that antithrombotic therapy is necessary in all patients with AF unless they are age = 3 represents a sufficiently high risk such that caution and/or regular review of a patient is needed. It also makes the clinician think of correctable common bleeding risk factors, and the availability of such a score allows an informed assessment of bleeding risk in AF patients, when antithrombotic therapy is being initiated.
Original languageEnglish
Pages (from-to)S21-S27
JournalClinical Cardiology
Volume35
DOIs
Publication statusPublished - 1 Jan 2012

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