cAMP/protein kinase A signalling pathway and adrenocortical adenomas

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Abstract

Multiple elements of the cAMP/protein kinase A (PKA) pathway have been shown to be mutated or deregulated in various endocrine disorders, indicating a major role of this pathway in the regulation of hormone secretion and also in tumorigenesis of endocrine cells. In particular, several alterations are known to be involved in the pathogenesis of adrenocortical adenomas associated with autonomous cortisol secretion. 

In this review, recent findings on cAMP/PKA alterations causative for the pathogenesis of benign unilateral cortisol-producing adrenocortical adenomas are summarized. Special emphasis is given to latest reports on newly identified mutations in genes encoding PKA catalytic subunits and their functional characterization.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalCurrent Opinion in Endocrine and Metabolic Research
Volume8
Early online date21 Jun 2019
DOIs
Publication statusPublished - 1 Oct 2019

Keywords

  • adrenal
  • cAMP
  • PKA
  • pathogenesis
  • therapy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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