Multiple elements of the cAMP/protein kinase A (PKA) pathway have been shown to be mutated or deregulated in various endocrine disorders, indicating a major role of this pathway in the regulation of hormone secretion and also in tumorigenesis of endocrine cells. In particular, several alterations are known to be involved in the pathogenesis of adrenocortical adenomas associated with autonomous cortisol secretion.
In this review, recent findings on cAMP/PKA alterations causative for the pathogenesis of benign unilateral cortisol-producing adrenocortical adenomas are summarized. Special emphasis is given to latest reports on newly identified mutations in genes encoding PKA catalytic subunits and their functional characterization.
|Number of pages
|Current Opinion in Endocrine and Metabolic Research
|Early online date
|21 Jun 2019
|Published - 1 Oct 2019
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism