Ca2+ regulation and gene expression in normal brain aging

Emil Toescu, A Verkhratsky, PW Landfield

    Research output: Contribution to journalArticle

    179 Citations (Scopus)


    Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.
    Original languageEnglish
    Pages (from-to)614-620
    Number of pages7
    JournalTrends in Neurosciences
    Publication statusPublished - 1 Oct 2004


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