Abstract
Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.
| Original language | English |
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| Pages (from-to) | 614-620 |
| Number of pages | 7 |
| Journal | Trends in Neurosciences |
| Volume | 27(10) |
| Publication status | Published - 1 Oct 2004 |