Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology

Martin Rowe; Gemma Kelly; Andrew Bell; Alan Rickinson

doi:10.1016/j.semcancer.2009.07.004

Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology

Martin Rowe, Gemma Kelly, Andrew Bell, Alan Rickinson

Cancer and Genomic Sciences

Research output: Contribution to journal › Article

67 Citations (Scopus)

Abstract

Epstein-Barr virus was originally identified in the tumour cells of a Burkitt's lymphoma, and was the first virus to be associated with the pathogenesis of a human cancer. Studies on the relationship of EBV with Burkitt's lymphoma have revealed important general principles that are relevant to other virus-associated cancers. In addition, the impact of such studies on the knowledge of EBV biology has been enormous. Here, we review some of the key historical observations arising from studies on Burkitt's lymphoma that have informed our understanding of EBV, and we summarise the current hypotheses regarding the role of EBV in the pathogenesis of Burkitt's lymphoma.

Original language	English
Pages (from-to)	377-88
Number of pages	12
Journal	Seminars in Cancer Biology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.semcancer.2009.07.004
Publication status	Published - 1 Dec 2009

Keywords

c-myc
Cancer pathogenesis
Burkitt's lymphoma
Epstein-Barr virus
Apoptosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcancer.2009.07.004

Epstein-Barr Virus Infections of B Lymphocytes and the Pathogenesis of Virus-Associated Lymphomas
Rickinson, A., Bell, A. & Rowe, M.
Cancer Research UK
1/01/08 → 31/12/12
Project: Research

Cite this

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abstract = "Epstein-Barr virus was originally identified in the tumour cells of a Burkitt's lymphoma, and was the first virus to be associated with the pathogenesis of a human cancer. Studies on the relationship of EBV with Burkitt's lymphoma have revealed important general principles that are relevant to other virus-associated cancers. In addition, the impact of such studies on the knowledge of EBV biology has been enormous. Here, we review some of the key historical observations arising from studies on Burkitt's lymphoma that have informed our understanding of EBV, and we summarise the current hypotheses regarding the role of EBV in the pathogenesis of Burkitt's lymphoma.",

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AU - Bell, Andrew

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AB - Epstein-Barr virus was originally identified in the tumour cells of a Burkitt's lymphoma, and was the first virus to be associated with the pathogenesis of a human cancer. Studies on the relationship of EBV with Burkitt's lymphoma have revealed important general principles that are relevant to other virus-associated cancers. In addition, the impact of such studies on the knowledge of EBV biology has been enormous. Here, we review some of the key historical observations arising from studies on Burkitt's lymphoma that have informed our understanding of EBV, and we summarise the current hypotheses regarding the role of EBV in the pathogenesis of Burkitt's lymphoma.

KW - c-myc

KW - Cancer pathogenesis

KW - Burkitt's lymphoma

KW - Epstein-Barr virus

KW - Apoptosis

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JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

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ER -

Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology

Abstract

Keywords

UN SDGs

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Projects

Epstein-Barr Virus Infections of B Lymphocytes and the Pathogenesis of Virus-Associated Lymphomas

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