Broadly expressed tumour-associated proteins as targets for cytotoxic T lymphocyte-based cancer immunotherapy

Gavin M Bendle, Angelika Holler, Anne-Marie Downs, Shao-An Xue, Hans J Stauss

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

T cell-based antigen-specific immunotherapy targeting self-proteins aberrantly expressed in many tumours offers the potential for widely applicable cancer immunotherapy, but carries the risk of autoimmunity. Immunological tolerance represents an inherent limitation of cancer vaccines targeting such broadly expressed tumour-associated proteins. Therefore, strategies to circumvent T cell tolerance have been developed and, when combined with T cell receptor (TCR) gene transfer technology, can generate highly avid tumour-reactive patient cytotoxic T lymphocytes (CTLs) specific for peptide epitopes of tumour-associated proteins. This review analyses the level of tolerance to broadly expressed tumour-associated proteins in the autologous T cell repertoire, assesses strategies that have been developed to circumvent T cell tolerance to such antigens, and evaluates the prospects for effective immunotherapy targeting broadly expressed tumour-associated proteins.
Original languageEnglish
Pages (from-to)1183-92
Number of pages10
JournalExpert Opinion in Biological Therapy
Volume5
Issue number9
DOIs
Publication statusPublished - Sep 2005

Keywords

  • Adoptive Transfer
  • Animals
  • Antigens, Neoplasm
  • Cancer Vaccines
  • Clinical Trials as Topic
  • Genetic Therapy
  • Humans
  • Immune Tolerance
  • Immunotherapy
  • Models, Animal
  • Neoplasms
  • Proto-Oncogene Proteins c-mdm2
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes, Cytotoxic

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