Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group

S L Kenyon; D J Taylor; W Tarnow-Mordi; ORACLE Collaboration

Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group

S L Kenyon, D J Taylor, W Tarnow-Mordi, ORACLE Collaboration

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453 Citations (Scopus)

Abstract

Preterm, prelabour rupture of the fetal membranes (pPROM) is the commonest antecedent of preterm birth, and can lead to death, neonatal disease, and long-term disability. Previous small trials of antibiotics for pPROM suggested some health benefits for the neonate, but the results were inconclusive. We did a randomised multicentre trial to try to resolve this issue.

Original language	English
Pages (from-to)	979-88
Number of pages	10
Journal	Lancet
Volume	357
Issue number	9261
Publication status	Published - 31 Mar 2001

Keywords

Adult
Amoxicillin-Potassium Clavulanate Combination
Anti-Bacterial Agents
Drug Therapy, Combination
Enterocolitis, Necrotizing
Erythromycin
Female
Fetal Membranes, Premature Rupture
Humans
Infant, Newborn
Obstetric Labor, Premature
Pregnancy
Pregnancy Outcome
Treatment Outcome

Cite this

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title = "Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group",

abstract = "Preterm, prelabour rupture of the fetal membranes (pPROM) is the commonest antecedent of preterm birth, and can lead to death, neonatal disease, and long-term disability. Previous small trials of antibiotics for pPROM suggested some health benefits for the neonate, but the results were inconclusive. We did a randomised multicentre trial to try to resolve this issue.",

keywords = "Adult, Amoxicillin-Potassium Clavulanate Combination, Anti-Bacterial Agents, Drug Therapy, Combination, Enterocolitis, Necrotizing, Erythromycin, Female, Fetal Membranes, Premature Rupture, Humans, Infant, Newborn, Obstetric Labor, Premature, Pregnancy, Pregnancy Outcome, Treatment Outcome",

author = "Kenyon, {S L} and Taylor, {D J} and W Tarnow-Mordi and {ORACLE Collaboration}",

year = "2001",

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day = "31",

language = "English",

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pages = "979--88",

journal = "Lancet",

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T1 - Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes

T2 - the ORACLE I randomised trial. ORACLE Collaborative Group

AU - Kenyon, S L

AU - Taylor, D J

AU - Tarnow-Mordi, W

AU - ORACLE Collaboration

PY - 2001/3/31

Y1 - 2001/3/31

N2 - Preterm, prelabour rupture of the fetal membranes (pPROM) is the commonest antecedent of preterm birth, and can lead to death, neonatal disease, and long-term disability. Previous small trials of antibiotics for pPROM suggested some health benefits for the neonate, but the results were inconclusive. We did a randomised multicentre trial to try to resolve this issue.

AB - Preterm, prelabour rupture of the fetal membranes (pPROM) is the commonest antecedent of preterm birth, and can lead to death, neonatal disease, and long-term disability. Previous small trials of antibiotics for pPROM suggested some health benefits for the neonate, but the results were inconclusive. We did a randomised multicentre trial to try to resolve this issue.

KW - Adult

KW - Amoxicillin-Potassium Clavulanate Combination

KW - Anti-Bacterial Agents

KW - Drug Therapy, Combination

KW - Enterocolitis, Necrotizing

KW - Erythromycin

KW - Female

KW - Fetal Membranes, Premature Rupture

KW - Humans

KW - Infant, Newborn

KW - Obstetric Labor, Premature

KW - Pregnancy

KW - Pregnancy Outcome

KW - Treatment Outcome

M3 - Article

C2 - 11293640

SN - 0140-6736

VL - 357

SP - 979

EP - 988

JO - Lancet

JF - Lancet

IS - 9261

ER -

Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group

Abstract

Keywords

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