British Gynaecological Cancer Society/British Association of Gynaecological Pathology consensus for germline and tumor testing for BRCA1/2 variants in ovarian cancer in the United Kingdom

Sudha Sundar, Ranjit Manchanda, Charlie Gourley, Angela George, Andrew Wallace, Janos Balega, Sarah Williams, Yvonne Wallis, Richard Edmondson, Shibani Nicum, Jonathan Frost, Ayoma Attygalle, Christina Fotopoulou, Rebecca Bowen, Dani Bell, Ketankumar Gajjar, Bruce Ramsay, Nicholas J Wood, Sadaf Ghaem-Maghami, Tracie MilesRaji Ganesan

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Abstract

The British Gynecological Cancer Society and the British Association of Gynecological Pathologists established a multidisciplinary consensus group comprising experts in surgical gynecological oncology, medical oncology, genetics, and laboratory science, and clinical nurse specialists to identify the optimal pathways to BRCA germline and tumor testing in patients with ovarian cancer in routine clinical practice. In particular, the group explored models of consent, quality standards identified at pathology laboratories, and experience and data from pioneering cancer centers. The group liaised with representatives from ovarian cancer charities to also identify patient perspectives that would be important to implementation. Recommendations from these consensus group deliberations are presented in this manuscript.

Original languageEnglish
Pages (from-to)272-278
Number of pages7
JournalInternational Journal of Gynecological Cancer
Volume31
Issue number2
DOIs
Publication statusPublished - 1 Feb 2021

Keywords

  • BRCA1 protein
  • BRCA2 protein
  • fallopian tube neoplasms
  • ovarian neoplasms

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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