Brachial-ankle pulse wave velocity and cardiovascular risk factors in the non-diabetic and newly diagnosed diabetic Chinese: Guangzhou Biobank Cohort Study-CVD

L Xu, CQ Jiang, TH Lam, XJ Yue, Kar Cheng, B Liu, YL Jin, WS Zhang, Graham Thomas

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    Background Increased arterial stiffness is an important cause of cardiovascular disease (CVD). We examined determinants of arterial stiffness in subjects across strata of glycaemic status. Methods A total of 1249 subjects from a sub-study of the Guangzhou Biobank Cohort Study (GBCS-CVD) had brachial-ankle pulse wave velocity (baPWV) measured by automatic oscillometric method. Major cardiovascular risk factors including glycosylated haemoglobin A1c (HbA(1c)), high sensitivity C-reactive protein (hsCRP), fasting triglyceride, low- and high-density lipoprotein cholesterol and both fasting and post 2-h oral glucose-load glucose, systolic and diastolic blood pressure were assessed. Results In all, 649, 479 and 121 subjects were classified into normoglycaemia, impaired glucose metabolism (IGM) and newly diagnosed diabetes groups, respectively. Both age and systolic blood pressure were significantly associated with increased baPWV in all three groups (all p <0.001). In both normoglycaemic and IGM groups, hsCRP and HbA(1c) were positively associated with baPWV (p from 0.04 to
    Original languageEnglish
    Pages (from-to)133-139
    Number of pages7
    JournalDiabetes/metabolism research and reviews
    Volume26
    Issue number2
    DOIs
    Publication statusPublished - 1 Feb 2010

    Keywords

    • pulse wave velocity
    • glycosylated haemoglobin A1c
    • normoglycaemia
    • arterial stiffness

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