Abstract
Acute cooling significantly increases energy demand in non-hibernators for the defence of core temperature but the contribution of the liver to thermogenesis is poorly understood. A two-tracer method to estimate lipid metabolism in cold-naive control (CON) and cold-acclimated (CA) rats was employed to quantify hepatic rates of fat metabolism. Both fenofibrate, to increase liver mass and fat oxidation and dichloroacetate (DCA) to inhibit fat oxidation were used to alter lipid metabolism in CON animals. Following acute cooling, CA led to a doubling of the time to reach a core temperature 25 degrees C (P
| Original language | English |
|---|---|
| Pages (from-to) | 514-522 |
| Number of pages | 9 |
| Journal | Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology |
| Volume | 154 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Dec 2009 |
Keywords
- Utilisation
- Fatty acid
- Metabolism
- Cold acclimation