TY - CHAP
T1 - BluePharmTrain
T2 - biology and Biotechnology of Marine Sponges
AU - Steinert, Georg
AU - Stauffer, Carla Huete
AU - Aas-valleriani, Nele
AU - Borchert, Erik
AU - Bhushan, Agneya
AU - Campbell, Alexandra
AU - De Mares, Maryam Chaib
AU - Costa, Margarida
AU - Gutleben, Johanna
AU - Knobloch, Stephen
AU - Lee, Robert Gregory
AU - Munroe, Stephanie
AU - Naik, Deepak
AU - Peters, Eike Edzard
AU - Stokes, Ellen
AU - Wang, Wanlin
AU - Einarsdóttir, Eydís
AU - Sipkema, Detmer
PY - 2018/5/16
Y1 - 2018/5/16
N2 - BluePharmTrain is a Marie Curie Initial Training Network of 17 European academic and industrial partners collaborating to train young scientists in multidisciplinary aspects of blue biotechnology. Harvesting marine sponges for the extraction of bioactive compounds is often highly unsustainable, and the chemical synthesis of promising compounds is often either too complex or very expensive. To find sustainable and economically feasible production methods of sponge-derived compounds, individual BluePharmTrain research projects explore innovative techniques, focusing on selected sponge species shown to harbour interesting active metabolites. The different techniques include sponge cell cultivation, cultivation of microbial symbionts, next-generation sequencing approaches (i.e. metagenomics and metatranscriptomics), in situ and ex situ cultivation of sponges, life cycle characterisation, chemical structure elucidation of compounds and compound metabolic pathway description. Altogether, these consorted efforts and collaborations lead to new insights on sponge metabolism, sponge-microbe interactions and bioactive compound production.
AB - BluePharmTrain is a Marie Curie Initial Training Network of 17 European academic and industrial partners collaborating to train young scientists in multidisciplinary aspects of blue biotechnology. Harvesting marine sponges for the extraction of bioactive compounds is often highly unsustainable, and the chemical synthesis of promising compounds is often either too complex or very expensive. To find sustainable and economically feasible production methods of sponge-derived compounds, individual BluePharmTrain research projects explore innovative techniques, focusing on selected sponge species shown to harbour interesting active metabolites. The different techniques include sponge cell cultivation, cultivation of microbial symbionts, next-generation sequencing approaches (i.e. metagenomics and metatranscriptomics), in situ and ex situ cultivation of sponges, life cycle characterisation, chemical structure elucidation of compounds and compound metabolic pathway description. Altogether, these consorted efforts and collaborations lead to new insights on sponge metabolism, sponge-microbe interactions and bioactive compound production.
U2 - 10.1007/978-3-319-69075-9_13
DO - 10.1007/978-3-319-69075-9_13
M3 - Chapter (peer-reviewed)
SN - 9783319690742
T3 - Grand Challenges in Marine Biotechnology
SP - 505
EP - 553
BT - Grand Challenges in Marine Biotechnology
A2 - Rampelotto, Pabulo
A2 - Trincone, Antonio
PB - Springer
ER -