BLIMP1 alpha, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas

Katerina Vrzalikova; Ciaran Woodman; Paul Murray

doi:10.5507/bp.2012.003

BLIMP1 alpha, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas

Katerina Vrzalikova, Ciaran Woodman, Paul Murray

Cancer and Genomic Sciences

Research output: Contribution to journal › Review article

11 Citations (Scopus)

Abstract

Aims. The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1 alpha as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
Volume	156
Issue number	1
DOIs	https://doi.org/10.5507/bp.2012.003
Publication status	Published - 1 Jan 2012

Keywords

DLBCL
Epstein-Barr virus
BLIMP1
review

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10.5507/bp.2012.003

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title = "BLIMP1 alpha, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas",

abstract = "Aims. The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1 alpha as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.",

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T1 - BLIMP1 alpha, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas

AU - Vrzalikova, Katerina

AU - Woodman, Ciaran

AU - Murray, Paul

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Aims. The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1 alpha as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.

AB - Aims. The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1 alpha as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.

KW - DLBCL

KW - Epstein-Barr virus

KW - BLIMP1

KW - review

U2 - 10.5507/bp.2012.003

DO - 10.5507/bp.2012.003

M3 - Review article

C2 - 22580854

VL - 156

SP - 1

EP - 6

JO - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

JF - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

IS - 1

ER -

BLIMP1 alpha, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas

Abstract

Keywords

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