Bipolar disorder and variation at a common polymorphism (A1832G) within exon 8 of the wolfram gene

Fiona Middle, Ian Jones, Fiona McCandless, Tim Barrett, Farhat Khanim, Michael J. Owen, Corinne Lendon, Nick Craddock*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


A number of linkage studies provide evidence consistent with the existence of a bipolar susceptibility gene on chromosome 4p16. The gene for Wolfram syndrome, a rare recessive neurodegenerative disorder, lies in this region and has recently been cloned. Psychiatric disturbances including psychosis, mood disorder, and suicide have been reported at increased frequency in Wolfram patients and in heterozygous carriers of a Wolfram mutation. In the current investigation we have undertaken a case-control association study using a single nucleotide polymorphism (causing an amino acid change) in exon 8 of the Wolfram gene in a UK Caucasian sample of 312 Diagnostic and Statistical Manual of Mental Disorders (fourth edition; DSM IV) bipolar I probands and 301 comparison individuals. We found no evidence that variation at this polymorphism influences susceptibility to bipolar disorder. It remains possible that variation at other sites within or near the Wolfram gene plays important roles in determining susceptibility to affective illness. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number2
Publication statusPublished - 3 Apr 2000


  • Bipolar disorder
  • Susceptibility gene
  • Wolfram syndrome gene

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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