Abstract
A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard bioluminescence imaging. Specifically, it is shown that when imaging sources at depths ranging from 5 to 15mm, estimates of total source strength are stable to within ±11% using tomography whilst values deduced by traditional methods vary 10-fold. Additionally, the tomographic approach correctly localises sources to within 1.5mm error in all cases considered.
Original language | English |
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Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Volume | 8799 |
DOIs | |
Publication status | Published - 25 Jun 2013 |