Bioluminescence Resonance Energy Transfer (BRET) Assay to Measure Gq Recruitment to the Ghrelin Receptor

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This protocol chapter outlines a guide for investigating ghrelin receptor activation of Gq signaling using Bioluminescence Resonance Energy Transfer (BRET). Focusing on the eBRET2 and NanoBRET™ variants, the chapter covers steps from cell culture to transfection, ligand stimulation, and BRET measurements, offering a robust protocol to examine the temporal aspects of Gq signaling in live cells. This methodology facilitates a nuanced understanding of Gq-mediated cellular responses, but also provides researchers with a valuable tool for dissecting other related signaling pathways.
Original languageEnglish
Title of host publicationCalcium Signaling
Subtitle of host publicationMethods and Protocols
EditorsCaroline M. Gorvin
PublisherHumana Press
Chapter5
Pages57-69
Number of pages14
Edition1
ISBN (Electronic)9781071641644
ISBN (Print)9781071641668
DOIs
Publication statusPublished - 13 Oct 2024

Publication series

NameMethods in Molecular Biology
PublisherHumana New York, NY
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Fingerprint

Dive into the research topics of 'Bioluminescence Resonance Energy Transfer (BRET) Assay to Measure Gq Recruitment to the Ghrelin Receptor'. Together they form a unique fingerprint.

Cite this