Bioinformatics, genomics and evolution of non-flagellar type-III secretion systems: a Darwinian perpective

Mark Pallen, Scott Beatson, Christopher Bailey

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

We review the biology of non-flagellar type-III secretion systems from a Darwinian perspective, highlighting the themes of evolution, conservation, variation and decay. The presence of these systems in environmental organisms such as Myxococcus, Desulfovibrio and Verrucomicrobium hints at roles beyond virulence. We review newly discovered sequence homologies (e.g., YopN/TyeA and SepL). We discuss synapomorphies that might be useful in formulating a taxonomy of type-III secretion. The problem of information overload is likely to be ameliorated by launch of a web site devoted to the comparative biology of type-III secretion (http://3base.bham.ac.uk). (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)201-229
Number of pages29
JournalFEMS Microbiology Reviews
Volume29
Issue number2
DOIs
Publication statusPublished - 1 Jan 2005

Keywords

  • chaperones
  • symbiosis
  • bacterial virulence
  • type-III secretion
  • homology
  • genomics
  • bioinformatics
  • evolution

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