Bioadhesive oesophageal bandages: protection against acid and pepsin injury

Man Tang; Peter Dettmar; Hannah Batchelor

doi:10.1016/j.ijpharm.2004.11.039

Bioadhesive oesophageal bandages: protection against acid and pepsin injury

Man Tang, Peter Dettmar, Hannah Batchelor

Pharmacy

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The rate of acid and pepsin diffusion through solutions of sodium alginate was measured using in vitro techniques. Previous work has demonstrated that solutions of alginate may adhere to the oesophagus for up to 60 min; this work measured their ability to protect the oesophageal epithelial surface from damage caused by refluxed acid and pepsin. Franz diffusion cells were used to measure the rate of acid and pepsin diffusion through an alginate layer. The effect of the type of alginate, alginate concentration and depth of alginate applied were investigated. The rate of both acid and pepsin diffusion was significantly reduced (ANOVA analysis; P

Original language	English
Pages (from-to)	169-77
Number of pages	9
Journal	International Journal of Pharmaceutics
Volume	292
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2004.11.039
Publication status	Published - 23 Mar 2005

Keywords

Alginates
Animals
Area Under Curve
Biological Dressings
Cell Membrane Permeability
Diffusion
Dosage Forms
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Esophagitis, Peptic
Esophagus
Gastric Acid
Gastric Mucosa
Gastroesophageal Reflux
Hexuronic Acids
Hydrogen-Ion Concentration
Pepsin A
Protons
Solutions
Swine
Tissue Adhesives
Viscosity

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10.1016/j.ijpharm.2004.11.039

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title = "Bioadhesive oesophageal bandages: protection against acid and pepsin injury",

abstract = "The rate of acid and pepsin diffusion through solutions of sodium alginate was measured using in vitro techniques. Previous work has demonstrated that solutions of alginate may adhere to the oesophagus for up to 60 min; this work measured their ability to protect the oesophageal epithelial surface from damage caused by refluxed acid and pepsin. Franz diffusion cells were used to measure the rate of acid and pepsin diffusion through an alginate layer. The effect of the type of alginate, alginate concentration and depth of alginate applied were investigated. The rate of both acid and pepsin diffusion was significantly reduced (ANOVA analysis; P",

keywords = "Alginates, Animals, Area Under Curve, Biological Dressings, Cell Membrane Permeability, Diffusion, Dosage Forms, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Esophagitis, Peptic, Esophagus, Gastric Acid, Gastric Mucosa, Gastroesophageal Reflux, Hexuronic Acids, Hydrogen-Ion Concentration, Pepsin A, Protons, Solutions, Swine, Tissue Adhesives, Viscosity",

author = "Man Tang and Peter Dettmar and Hannah Batchelor",

year = "2005",

month = mar,

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doi = "10.1016/j.ijpharm.2004.11.039",

language = "English",

volume = "292",

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journal = "International Journal of Pharmaceutics",

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T1 - Bioadhesive oesophageal bandages

T2 - protection against acid and pepsin injury

AU - Tang, Man

AU - Dettmar, Peter

AU - Batchelor, Hannah

PY - 2005/3/23

Y1 - 2005/3/23

N2 - The rate of acid and pepsin diffusion through solutions of sodium alginate was measured using in vitro techniques. Previous work has demonstrated that solutions of alginate may adhere to the oesophagus for up to 60 min; this work measured their ability to protect the oesophageal epithelial surface from damage caused by refluxed acid and pepsin. Franz diffusion cells were used to measure the rate of acid and pepsin diffusion through an alginate layer. The effect of the type of alginate, alginate concentration and depth of alginate applied were investigated. The rate of both acid and pepsin diffusion was significantly reduced (ANOVA analysis; P

AB - The rate of acid and pepsin diffusion through solutions of sodium alginate was measured using in vitro techniques. Previous work has demonstrated that solutions of alginate may adhere to the oesophagus for up to 60 min; this work measured their ability to protect the oesophageal epithelial surface from damage caused by refluxed acid and pepsin. Franz diffusion cells were used to measure the rate of acid and pepsin diffusion through an alginate layer. The effect of the type of alginate, alginate concentration and depth of alginate applied were investigated. The rate of both acid and pepsin diffusion was significantly reduced (ANOVA analysis; P

KW - Alginates

KW - Animals

KW - Area Under Curve

KW - Biological Dressings

KW - Cell Membrane Permeability

KW - Diffusion

KW - Dosage Forms

KW - Dose-Response Relationship, Drug

KW - Drug Evaluation, Preclinical

KW - Esophagitis, Peptic

KW - Esophagus

KW - Gastric Acid

KW - Gastric Mucosa

KW - Gastroesophageal Reflux

KW - Hexuronic Acids

KW - Hydrogen-Ion Concentration

KW - Pepsin A

KW - Protons

KW - Solutions

KW - Swine

KW - Tissue Adhesives

KW - Viscosity

U2 - 10.1016/j.ijpharm.2004.11.039

DO - 10.1016/j.ijpharm.2004.11.039

M3 - Article

C2 - 15725563

SN - 0378-5173

VL - 292

SP - 169

EP - 177

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Bioadhesive oesophageal bandages: protection against acid and pepsin injury

Abstract

Keywords

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