Bioadhesive oesophageal bandages: protection against acid and pepsin injury

Man Tang, Peter Dettmar, Hannah Batchelor

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


The rate of acid and pepsin diffusion through solutions of sodium alginate was measured using in vitro techniques. Previous work has demonstrated that solutions of alginate may adhere to the oesophagus for up to 60 min; this work measured their ability to protect the oesophageal epithelial surface from damage caused by refluxed acid and pepsin. Franz diffusion cells were used to measure the rate of acid and pepsin diffusion through an alginate layer. The effect of the type of alginate, alginate concentration and depth of alginate applied were investigated. The rate of both acid and pepsin diffusion was significantly reduced (ANOVA analysis; P
Original languageEnglish
Pages (from-to)169-77
Number of pages9
JournalInternational Journal of Pharmaceutics
Issue number1-2
Publication statusPublished - 23 Mar 2005


  • Alginates
  • Animals
  • Area Under Curve
  • Biological Dressings
  • Cell Membrane Permeability
  • Diffusion
  • Dosage Forms
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Esophagitis, Peptic
  • Esophagus
  • Gastric Acid
  • Gastric Mucosa
  • Gastroesophageal Reflux
  • Hexuronic Acids
  • Hydrogen-Ion Concentration
  • Pepsin A
  • Protons
  • Solutions
  • Swine
  • Tissue Adhesives
  • Viscosity


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