Projects per year
Abstract
Lymphangiogenesis associated with tertiary lymphoid structure (TLS) has been reported in numerous studies. However, the kinetics and dynamic changes occurring to the lymphatic vascular network during TLS development have not been studied. Using a viral-induced, resolving model of TLS formation in the salivary glands of adult mice we demonstrate that the expansion of the lymphatic vascular network is tightly regulated. Lymphatic vessel expansion occurs in two distinct phases. The first wave of expansion is dependent on IL-7. The second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (LT)βR signaling. These findings, while highlighting the tight regulation of the lymphatic response to inflammation, suggest that targeting the LTα1β2/LTβR pathway in TLS-associated pathologies might impair a natural proresolving mechanism for lymphocyte exit from the tissues and account for the failure of therapeutic strategies that target these molecules in diseases such as rheumatoid arthritis.
Original language | English |
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Pages (from-to) | 1957-1967 |
Number of pages | 11 |
Journal | Journal of Immunology |
Volume | 197 |
Issue number | 5 |
Early online date | 29 Jul 2016 |
DOIs | |
Publication status | Published - 1 Sept 2016 |
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Dive into the research topics of 'Bimodal expansion of the lymphatic vessels is regulated by the sequential expression of IL-7 and lymphotoxin α1β2 in newly formed tertiary lymphoid structures'. Together they form a unique fingerprint.Projects
- 3 Finished
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Lymphotoxin Beta Receptor Signalling Effects on Adipogenic Differentiation
Caamano, J., Hewett, P. & O'Neill, L.
Biotechnology & Biological Sciences Research Council
18/11/13 → 31/01/17
Project: Research Councils
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MRC Centre For Immune Regulation (Linked to DCDF.RRAK10540) (Linked to 14810 & 14835)
Jenkinson, E.
3/08/09 → 30/09/17
Project: Research Councils