Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols

Zheng Wang, Jinjin Ye, Rui Wu, Yang Zi Liu, John S. Fossey, Jiagao Cheng*, Wei Ping Deng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Chiral nucleophilic catalysts, 6-aryl-phenyl-dihydroimidazoquinolines (PIQs), were designed, synthesised and applied to the kinetic resolution of arylalkyl carbinols with very high selectivity (S) factors (up to 530). Density functional theory calculations indicate that multiple noncovalent interactions play a key role in chiral recognition between 6-aryl-PIQ catalysts and chiral secondary alcohol substrates.

Original languageEnglish
Pages (from-to)1909-1913
Number of pages5
JournalCatalysis Science and Technology
Volume4
Issue number7
DOIs
Publication statusPublished - 1 Jan 2014

ASJC Scopus subject areas

  • Catalysis

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