Bench to Bedside: Modelling Inflammatory Arthritis

Chiamaka I Chidomere, Mussarat Wahid, Samuel Kemble, Caroline Chadwick, Richard Thomas, Rowan S Hardy, Helen M Mcgettrick*, Amy J Naylor*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Inflammatory arthritides such as rheumatoid arthritis are a major cause of disability. Pre-clinical murine models of inflammatory arthritis continue to be invaluable tools with which to identify and validate therapeutic targets and compounds. The models used are well-characterised and, whilst none truly recapitulates the human disease, they are crucial to researchers seeking to identify novel therapeutic targets and to test efficacy during preclinical trials of novel drug candidates.

The arthritis parameters recorded during clinical trials and routine clinical patient care have been carefully standardised, allowing comparison between centres, trials, and treatments. Similar standardisation of scoring across in vivo models has not occurred, which makes interpretation of published results, and comparison between arthritis models, challenging. Here, we include a detailed and readily implementable arthritis scoring system, that increases the breadth of arthritis characteristics captured during experimental arthritis and supports responsive and adaptive monitoring of disease progression in murine models of inflammatory arthritis.

In addition, we reference the wider ethical and experimental factors researchers should consider during the experimental design phase, with emphasis on the continued importance of replacement, reduction, and refinement of animal usage in arthritis research.
Original languageEnglish
Article numberkyac010
JournalDiscovery Immunology
Volume2
Issue number1
Early online date23 Nov 2022
DOIs
Publication statusPublished - 17 Jan 2023

Keywords

  • Rheumatoid arthritis
  • TNF
  • murine models of arthritis
  • 3Rs
  • clinical score

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