Behavioural memory reconsolidation of food and fear memories.

Charlotte Flavell, David Barber, Jonathan Lee

Research output: Contribution to journalArticle

77 Citations (Scopus)
195 Downloads (Pure)

Abstract

The reactivation of a memory through retrieval can render it subject to disruption or modification through the process of memory reconsolidation. In both humans and rodents, briefly reactivating a fear memory results in effective erasure by subsequent extinction training. Here we show that a similar strategy is equally effective in the disruption of appetitive pavlovian cue-food memories. However, systemic administration of the NMDA receptor partial agonist D-cycloserine, under the same behavioural conditions, did not potentiate appetitive memory extinction, suggesting that reactivation does not enhance subsequent extinction learning. To confirm that reactivation followed by extinction reflects a behavioural analogue of memory reconsolidation, we show that prevention of contextual fear memory reactivation by the L-type voltage-gated calcium channel blocker nimodipine interferes with the amnestic outcome. Therefore, the reconsolidation process can be manipulated behaviourally to disrupt both aversive and appetitive memories.
Original languageEnglish
Pages (from-to)504
Number of pages1
JournalNature Communications
Volume2
DOIs
Publication statusPublished - 1 Jan 2011

Fingerprint

Dive into the research topics of 'Behavioural memory reconsolidation of food and fear memories.'. Together they form a unique fingerprint.

Cite this