Behçet's syndrome: a multidisciplinary approach to clinical care

A J Whallett, G Thurairajan, J Hamburger, R G Palmer, P I Murray

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Behçet's syndrome is a multisystem disorder characterized by recurrent orogenital ulceration and an occlusive vasculitis. Histologically, there is a combination of a perivascular lymphocytic infiltration with endothelial cell damage coupled with a pro-thrombotic tendency. We present a multidisciplinary approach to the management of Behçet's syndrome, and compare our findings with other published studies. Over a nine-year period, 50 patients with Behçet's syndrome were followed in a multidisciplinary combined clinic. Patients were assessed by an ophthalmologist, a rheumatologist and a specialist in oral medicine. Data on disease activity and damage were collected using a standardized proforma for each specialty. Mean age of onset was 30 years; 56% were male. Recurrent oral ulceration was the commonest manifestation and the presenting feature in 76%. The commonest second systems involved were genital mucosae and eyes. We found a larger proportion of patients with ophthalmic (80%) and central nervous system (14%) manifestations compared with many other studies. There was an association between central nervous system and thrombotic events (p
Original languageEnglish
Pages (from-to)727-40
Number of pages14
Issue number12
Publication statusPublished - 1999


Dive into the research topics of 'Behçet's syndrome: a multidisciplinary approach to clinical care'. Together they form a unique fingerprint.

Cite this