TY - JOUR
T1 - B-cell memory and the persistence of antibody responses
AU - MacLennan, Ian
AU - Garcia de Vineusa de la Concha, Carola
AU - Casamayor-Palleja, M
PY - 2000/3/29
Y1 - 2000/3/29
N2 - Antigens such as viral envelope proteins and bacterial exotoxins induce responses which result in the production of neutralizing antibody. These responses persist for years and provide highly efficient defence against reinfection. During these antibody responses a proportion of participating B cells mutate the genes that encode their immunoglobulin variable regions. This can increase the affinity of the antibody, but can also induce autoreactive B cells. Selection mechanisms operate which allow the cells with high affinity for the provoking antigen to persist, while other B cells recruited into the response die.
AB - Antigens such as viral envelope proteins and bacterial exotoxins induce responses which result in the production of neutralizing antibody. These responses persist for years and provide highly efficient defence against reinfection. During these antibody responses a proportion of participating B cells mutate the genes that encode their immunoglobulin variable regions. This can increase the affinity of the antibody, but can also induce autoreactive B cells. Selection mechanisms operate which allow the cells with high affinity for the provoking antigen to persist, while other B cells recruited into the response die.
UR - http://www.scopus.com/inward/record.url?scp=79956209154&partnerID=8YFLogxK
U2 - 10.1098/rstb.2000.0571
DO - 10.1098/rstb.2000.0571
M3 - Article
C2 - 10794052
SN - 1471-2954
SN - 1471-2970
VL - 355
SP - 345
EP - 350
JO - Royal Society of London. Philosophical Transactions B. Biological Sciences
JF - Royal Society of London. Philosophical Transactions B. Biological Sciences
ER -