Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly

John Fossey

doi:10.1101/2020.09.03.281170

Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly

John Fossey

Chemistry

Research output: Other contribution

Abstract

Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-resistant MDR-TB and extensively-drug-resistant XDR-TB, therefore new drugs and new drug targets are urgently required. From a whole-cell phenotypic screen a series of azetidines derivatives termed BGAz, that elicit potent bactericidal activity with MIC99 values

Original language	English
DOIs	https://doi.org/10.1101/2020.09.03.281170
Publication status	Published - 3 Sept 2020

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title = "Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly",

abstract = "Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-resistant MDR-TB and extensively-drug-resistant XDR-TB, therefore new drugs and new drug targets are urgently required. From a whole-cell phenotypic screen a series of azetidines derivatives termed BGAz, that elicit potent bactericidal activity with MIC99 values ",

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AB - Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-resistant MDR-TB and extensively-drug-resistant XDR-TB, therefore new drugs and new drug targets are urgently required. From a whole-cell phenotypic screen a series of azetidines derivatives termed BGAz, that elicit potent bactericidal activity with MIC99 values

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M3 - Other contribution

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Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly

Abstract

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