Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation

Mingli Li; Jillian L Lindblad; Ernesto Perez; Andreas Bergmann; Yun Fan

doi:10.1186/s12915-016-0293-y

Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation

Mingli Li, Jillian L Lindblad, Ernesto Perez, Andreas Bergmann, Yun Fan

Biosciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

BACKGROUND: ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer.

RESULTS: Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development.

CONCLUSION: In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.

Original language	English
Journal	BMC Biology
Volume	14
Issue number	70
DOIs	https://doi.org/10.1186/s12915-016-0293-y
Publication status	Published - 19 Aug 2016

Keywords

Apoptosis-induced proliferation
Jun-N-terminal kinase signaling
Autophagy
Atg1
ULK1/2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12915-016-0293-yLicence: Creative Commons: Attribution (CC BY)

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title = "Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation",

abstract = "BACKGROUND: ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer.RESULTS: Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development.CONCLUSION: In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.",

keywords = "Apoptosis-induced proliferation, Jun-N-terminal kinase signaling, Autophagy, Atg1, ULK1/2",

author = "Mingli Li and Lindblad, {Jillian L} and Ernesto Perez and Andreas Bergmann and Yun Fan",

year = "2016",

month = aug,

day = "19",

doi = "10.1186/s12915-016-0293-y",

language = "English",

volume = "14",

journal = "BMC Biology",

issn = "1741-7007",

publisher = "Springer",

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TY - JOUR

T1 - Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation

AU - Li, Mingli

AU - Lindblad, Jillian L

AU - Perez, Ernesto

AU - Bergmann, Andreas

AU - Fan, Yun

PY - 2016/8/19

Y1 - 2016/8/19

N2 - BACKGROUND: ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer.RESULTS: Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development.CONCLUSION: In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.

AB - BACKGROUND: ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer.RESULTS: Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development.CONCLUSION: In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.

KW - Apoptosis-induced proliferation

KW - Jun-N-terminal kinase signaling

KW - Autophagy

KW - Atg1

KW - ULK1/2

U2 - 10.1186/s12915-016-0293-y

DO - 10.1186/s12915-016-0293-y

M3 - Article

C2 - 27542914

SN - 1741-7007

VL - 14

JO - BMC Biology

JF - BMC Biology

IS - 70

ER -

Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation

Abstract

Keywords

UN SDGs

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