Autophagy and the liver

Yannick Bailly (Editor), Ricky Bhogal, Simon Afford

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

162 Downloads (Pure)

Abstract

Autophagy is a cellular process that involves lysosomal degradation and recycling of intracellular organelles and proteins to maintain energy homeostasis during times of cellular stress [1]. It also serves to remove damaged cellular components such as mitochondria and long-lived proteins. Autophagy is catabolic mechanism and although hepatic autophagy performs the standard functions of degrading damaged organelles/aggregated proteins and regulating cell death it also regulates lipid accumulation within the liver. Autophagy can be divided into three distinct sub-groups that are discussed below. This chapter focuses upon the role of autophagy in a variety of liver diseases including hepatocellular carcinoma (HCC) and viral hepatitis. The increased understanding of the cellular machinery regulating autophagy within the liver may foster the development of therapeutic strategies that will ultimately help treat liver disease.
Original languageEnglish
Title of host publicationAutophagy - A Double-Edged Sword - Cell Survival or Death?
PublisherInTech
Pages165-185
ISBN (Electronic)9789535110620
DOIs
Publication statusPublished - 17 Apr 2013

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