Autoimmune Cytopenias Developing Late Post Alemtuzumab-Based Allogeneic Stem Cell Transplantation: Presentation of Short Case Series from a Transplant Center

Rebecca Lloyd, Emmanouil Nikolousis, Bhuvan Kishore, Richard Lovell, Paneesha Shankara, Nervana Abou Zeid, Claire Horgan, Alkistis Kyra Panteliadou, Graham McIlroy, Evgenia Xenou, Maria Kaparou, Kathleen Holder, Vidhya Murthy, Alexandros Kanellopoulos

Research output: Contribution to journalArticlepeer-review

Abstract

Stem cell transplantation remains the curative option for many patients with hematological malignancies. The long-term effects of these treatments on the patients and their immune systems have been extensively investigated, but there remains a paucity of data regarding autoimmune manifestations post-transplant, although these effects are well recognized. Herein we present the clinical picture and therapeutic approach in three patients (cases 1–3), with varied presentations of autoimmune disease post-transplant. Case 1 exhibited autoimmune hemolytic anemia and other autoimmune manifestations (serositis, thyroiditis), that were probably linked to graft versus relapsed leukemia effect. Cases 2 and 3 had pure red white cell aplasia and pure red cell aplasia, respectively, which were associated with hyperglobulinemia and a clonal T cell expansion.

Original languageEnglish
JournalCell transplantation
Volume29
DOIs
Publication statusPublished - 2020

Bibliographical note

Publisher Copyright:
© The Author(s) 2020.

Keywords

  • autoimmune disease
  • bone marrow transplant
  • graft versus host disease
  • hematopoietic stem cells
  • t cells

ASJC Scopus subject areas

  • Medicine(all)

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