Auto-regressive Discrete Acquisition Points Transformation for Diffusion Weighted MRI Data

Emma Metcalfe-Smith, Emma Meeus, Jan Novak, Hamid Dehghani, Andrew Peet, Niloufar Zarinabad

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
209 Downloads (Pure)


OBJECTIVE: A new method for fitting diffusion-weighted magnetic resonance imaging (DW-MRI) data composed of an unknown number of multi-exponential components is presented and evaluated. METHODS: The auto-regressive discrete acquisition points transformation (ADAPT) method is an adaption of the auto-regressive moving average system, which allows for the modeling of multi-exponential data and enables the estimation of the number of exponential components without prior assumptions. ADAPT was evaluated on simulated DW-MRI data. The optimum ADAPT fit was then applied to human brain DWI data and the correlation between the ADAPT coefficients and the parameters of the commonly used bi-exponential intravoxel incoherent motion (IVIM) method were investigated. RESULTS: The ADAPT method can correctly identify the number of components and model the exponential data. The ADAPT coefficients were found to have strong correlations with the IVIM parameters. ADAPT(1,1)-β0 correlated with IVIM-D: ρ = 0.708, P < 0.001. ADAPT(1,1)-α1 correlated with IVIM-f: ρ = 0.667, P < 0.001. ADAPT(1,1)-β1 correlated with IVIM-D*: ρ = 0.741, P < 0.001). CONCLUSION: ADAPT provides a method that can identify the number of exponential components in DWI data without prior assumptions, and determine potential complex diffusion biomarkers. SIGNIFICANCE: ADAPT has the potential to provide a generalized fitting method for discrete multi-exponential data, and determine meaningful coefficients without prior information.

Original languageEnglish
Pages (from-to)2617-2628
Number of pages12
JournalIEEE Transactions on Biomedical Engineering
Issue number9
Early online date24 Jan 2019
Publication statusPublished - Sept 2019

ASJC Scopus subject areas

  • Biomedical Engineering


Dive into the research topics of 'Auto-regressive Discrete Acquisition Points Transformation for Diffusion Weighted MRI Data'. Together they form a unique fingerprint.

Cite this