Atypical chemokine receptors.

Maria Ulvmar, Elin Hub, Antal Rot

Research output: Contribution to journalArticle

70 Citations (Scopus)


Atypical chemokine receptors (ACRs) are cell surface receptors with seven transmembrane domains structurally homologous to chemokine G-protein coupled receptors (GPCRs). However, upon ligation by cognate chemokines, ACRs fail to induce classical signaling and downstream cellular responses characteristic for GPCRs. Despite this, by affecting chemokine availability and function, ACRs impact on a multitude of pathophysiological events and have emerged as important molecular players in health and disease. This review discusses individual characteristics of the currently known ACRs, highlights their similarities and differences and attempts to establish their group identity. It summarizes the progress made in mapping ACR expression, understanding their diverse in vitro and in vivo functions of ACRs and uncovering their contributions to disease pathogeneses.
Original languageEnglish
Pages (from-to)556-68
Number of pages13
JournalExperimental Cell Research
Issue number5
Publication statusPublished - 10 Mar 2011


Dive into the research topics of 'Atypical chemokine receptors.'. Together they form a unique fingerprint.

Cite this