Attempts to improve treatment outcomes in acute myeloid leukaemia in older patients: the results of the UK Medical Research Council AML11 Trial

AH Goldstone, AK Burnett, Keith Wheatley, AG Smith, RM Hutchinson, RE Clark

Research output: Contribution to journalArticle

337 Citations (Scopus)

Abstract

In an attempt to improve induction chemotherapy for older patients with acute myeloid leukemia (AML), 1314 patients were randomized to 1 of 3 induction treatments for 2 courses of DAT (daunorubicin, cytarabine, and thioguanine) 3 + 10, ADE (daunorubicin, cytarabine, and etoposide) 10 + 3 + 5, or MAC (mitoxantronecytarabine). The remission rate In the DAT arm was significantly better than AIDE (62% vs 50%; P = .002) or MAC (62% vs 55%; P = .04). This benefit was seen in patients younger and older than 70 years. There were no differences between the induction schedules with respect to overall survival at 5 years (12% vs 8% vs 10%). A total of 226 patients were randomized to receive granulocyte colony-stimulating factor (G-CSF) or placebo as supportive care from day 8 after the end of treatment course 1. The remission rate or survival were not improved by G-CSF, although the median number of days to recover neutrophils to 1.0 x 10(9)/L was reduced by 5 days. Patients who entered remission (n = 371) were randomized to stop after a third course (DAT 2 + 7) or after 6 courses, le, a subsequent COAP (cyclophosphamide, vincristine, cytarabine, and prednisolone), DAT 2 + 5, and COAP. The relapse risk (81% VS 73%), disease-free survival (16% vs; 23%), and overall survival at 5 years (23% vs 22%) did not differ between the 3-course or 6-course arms. In addition to a treatment duration randomization, 362 patients were randomized to receive 12-month maintenance treatment with low-dose interferon, but no benefit was seen with respect to relapse risk, disease-free survival, or overall survival. (C) 2001 by The American Society of Hematology.
Original languageEnglish
Pages (from-to)1302-1311
Number of pages10
JournalBlood
Volume98
Issue number5
DOIs
Publication statusPublished - 1 Sep 2001

Fingerprint

Dive into the research topics of 'Attempts to improve treatment outcomes in acute myeloid leukaemia in older patients: the results of the UK Medical Research Council AML11 Trial'. Together they form a unique fingerprint.

Cite this