TY - JOUR
T1 - Atrial disease and heart failure
T2 - the common soil hypothesis proposed by the Heart Failure Association of the European Society of Cardiology
AU - Coats, Andrew J S
AU - Heymans, Stephane
AU - Farmakis, Dimitrios
AU - Anker, Stefan D
AU - Backs, Johannes
AU - Bauersachs, Johann
AU - De boer, Rudolf A
AU - Čelutkienė, Jelena
AU - Cleland, John G F
AU - Dobrev, Dobromir
AU - Van gelder, Isabelle C
AU - Von haehling, Stephan
AU - Hindricks, Gerhard
AU - Jankowska, Ewa
AU - Kotecha, Dipak
AU - Van laake, Linda W
AU - Lainscak, Mitja
AU - Lund, Lars H
AU - Lunde, Ida Gjervold
AU - Lyon, Alexander R
AU - Manouras, Aristomenis
AU - Miličić, Davor
AU - Mueller, Christian
AU - Polovina, Marija
AU - Ponikowski, Piotr
AU - Rosano, Giuseppe
AU - Seferović, Petar M
AU - Tschöpe, Carsten
AU - Wachter, Rolf
AU - Ruschitzka, Frank
PY - 2022/3/1
Y1 - 2022/3/1
N2 - A proposed conceptual framework for understanding atrial disease. Subclinical atrial disease develops under the effect of stressors such as aging, cardio-metabolic risk factors and diseases, and genetic predisposition that activate pathogenic mechanisms, such as inflammation, endothelial and microvascular dysfunction, fibrosis, hypercoagulability and atrial stretch that in turn affect the atrial myocardium. Subclinical atrial disease is characterized by structural, electrical and functional changes, also termed atrial remodelling, that progress to overt clinical disease, manifesting as atrial fibrillation, heart failure and further to thromboembolism. The potential detection of subclinical atrial disease with imaging, biomarkers and other modalities offers a window opportunity for interventions that would prevent deterioration to clinical disease and could potentially allow reversal of subclinical disease. CMR, cardiac magnetic resonance; CT, computed tomography; ECG, electrocardiogram; RF, risk factors.
AB - A proposed conceptual framework for understanding atrial disease. Subclinical atrial disease develops under the effect of stressors such as aging, cardio-metabolic risk factors and diseases, and genetic predisposition that activate pathogenic mechanisms, such as inflammation, endothelial and microvascular dysfunction, fibrosis, hypercoagulability and atrial stretch that in turn affect the atrial myocardium. Subclinical atrial disease is characterized by structural, electrical and functional changes, also termed atrial remodelling, that progress to overt clinical disease, manifesting as atrial fibrillation, heart failure and further to thromboembolism. The potential detection of subclinical atrial disease with imaging, biomarkers and other modalities offers a window opportunity for interventions that would prevent deterioration to clinical disease and could potentially allow reversal of subclinical disease. CMR, cardiac magnetic resonance; CT, computed tomography; ECG, electrocardiogram; RF, risk factors.
U2 - 10.1093/eurheartj/ehab834
DO - 10.1093/eurheartj/ehab834
M3 - Article
SN - 0195-668X
VL - 43
SP - 863
EP - 867
JO - European Heart Journal
JF - European Heart Journal
IS - 9
ER -