AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

Amanda Acevedo-Jake; Andrew T. Ball; Marzia Galli; Mikiembo Kukwikila; Mathieu Denis; Daniel G. Singleton; Ali Tavassoli; Stephen M. Goldup

doi:10.1021/jacs.0c01670

AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

Amanda Acevedo-Jake, Andrew T. Ball, Marzia Galli, Mikiembo Kukwikila, Mathieu Denis, Daniel G. Singleton, Ali Tavassoli^*, Stephen M. Goldup

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

Original language	English
Pages (from-to)	5985-5990
Number of pages	6
Journal	Journal of the American Chemical Society
Volume	142
Issue number	13
DOIs	https://doi.org/10.1021/jacs.0c01670
Publication status	Published - 1 Apr 2020

Bibliographical note

Funding Information:
We thank the University of Southampton, EPSRC (EP/L016621/1), BBSRC (BB/J001694/2), and ERC (724987) for financial support. M.G. thanks the EPRSC for a Doctoral Prize. A.A.J. is a Marie-Curie Fellow (798304). S.M.G. is a Royal Society Wolfson Research Fellow.

Publisher Copyright:
Copyright © 2020 American Chemical Society.

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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title = "AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides",

abstract = "We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.",

author = "Amanda Acevedo-Jake and Ball, \{Andrew T.\} and Marzia Galli and Mikiembo Kukwikila and Mathieu Denis and Singleton, \{Daniel G.\} and Ali Tavassoli and Goldup, \{Stephen M.\}",

note = "Funding Information: We thank the University of Southampton, EPSRC (EP/L016621/1), BBSRC (BB/J001694/2), and ERC (724987) for financial support. M.G. thanks the EPRSC for a Doctoral Prize. A.A.J. is a Marie-Curie Fellow (798304). S.M.G. is a Royal Society Wolfson Research Fellow. Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society.",

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AU - Acevedo-Jake, Amanda

AU - Ball, Andrew T.

AU - Galli, Marzia

AU - Kukwikila, Mikiembo

AU - Denis, Mathieu

AU - Singleton, Daniel G.

AU - Tavassoli, Ali

AU - Goldup, Stephen M.

N1 - Funding Information: We thank the University of Southampton, EPSRC (EP/L016621/1), BBSRC (BB/J001694/2), and ERC (724987) for financial support. M.G. thanks the EPRSC for a Doctoral Prize. A.A.J. is a Marie-Curie Fellow (798304). S.M.G. is a Royal Society Wolfson Research Fellow. Publisher Copyright: Copyright © 2020 American Chemical Society.

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AB - We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

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ER -

AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

Abstract

Bibliographical note

ASJC Scopus subject areas

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