Associations of meat, fish and seafood consumption with kidney function in middle-aged to older Chinese: a cross-sectional study based on the Guangzhou Biobank Cohort Study

Objective: To examine the associations of red meat, poultry, fish and seafood and processed meat consumption with kidney function in middle-aged to older Chinese.

Design: A cross-sectional study based on the Guangzhou Biobank Cohort Study.

Setting: Community-based sample.

Participants: 9768 participants (2743 men and 7025 women) aged 50+ years.

Primary and secondary outcome measures: Primary outcome was estimated glomerular filtration rate (eGFR) derived from the Chinese-specific equation based on the Modification of Diet in Renal Disease (MDRD) equation (c-aGFR). eGFR derived from the original isotope-dilution mass spectrometry-traceable MDRD study equation, and prevalent chronic kidney disease (CKD) defined as c-aGFR
Results After adjusting for sex, age, body mass index, education, occupation, family income, smoking status, alcohol use, physical activity, daily energy intake, self-rated health and chronic disease history (diabetes, hypertension and dyslipidaemia), compared with processed meat consumption of 0–1 portion/week, those who consumed ≥3 portions/week had lower c-aGFR (β=−2.74 mL/min/1.73 m2, 95% CI=−4.28 to −1.20) and higher risk of prevalent CKD (OR=1.40, 95% CI=1.09 to 1.80, p
Conclusions Higher processed meat, fish and seafood consumption was associated with lower kidney function in normoglycaemic participants. However, the associations in participants with diabetes warrant further investigation.