Associations between spirometry parameters and limitations in daily life activities in patients with schizophrenia

Davy Vancampfort, Michel Probst, Brendon Stubbs, Andrew Soundy, Amber De Herdt, Marc De Hert

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objective This cross-sectional study considered whether variability in respiratory functioning could explain the variability in walking ability of individuals with schizophrenia taking into account variability in body mass index (BMI), lifestyle factors, psychiatric symptoms, antipsychotic medication use and muscular fitness. Method Eighty patients with schizophrenia and 40 age-, gender- and BMI-matched controls underwent a spirometry and the 6-min walk test (6MWT) and completed the International Physical Activity Questionnaire. Patients were additionally screened for psychiatric symptoms. Results Compared to health controls, patients with schizophrenia achieved a lower distance on the 6MWT (583.6±109.7 m versus 710.6±108.4 m, P< .001) and had a lower forced vital capacity (3.7±1.1 L versus 4.3±0.9 L, P< .001) and forced expiratory volume in 1 s (FEV1) (3.0±1.0 L versus 3.6±0.7 L, P< .001). In multiple regression analysis, 68.1% of the variance in walking distance was explained by FEV1, BMI, muscular fitness and total energy expenditure. Conclusion The respiratory health of patients with schizophrenia should be of concern for clinicians. In addition, future research interventions should seek to investigate the impact of an impaired respiratory health upon individuals with schizophrenia.
Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalGeneral Hospital Psychiatry
Issue number2
Early online date12 Nov 2013
Publication statusPublished - Mar 2014


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