Association of two apolipoprotein A-I gene MspI polymorphisms with lipid and blood pressure levels

Yan Qing Ma, G Neil Thomas, Brian Tomlinson

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    INTRODUCTION: Two MspI polymorphisms in the ApoA-I gene (G-75A and C83T) have been shown to be associated with plasma HDL-cholesterol levels.

    METHODS: We used a PCR-based RFLP method to determine the association of these polymorphisms with lipid parameters in 271 non-diabetic, normotriglyceridaemic Chinese subjects, of whom 104 were patients with hypertension, with 10.2% having hypercholesterolaemia and the remainder were controls.

    RESULTS: As expected, the hypertensive group had higher blood pressure and indices of obesity, and a more adverse lipid profile. No differences in the ApoA-I G-75A genotype or allele frequency distributions between the controls and patients were identified. However, there was a significantly lower frequency of the CT genotype (p=0.012) and T allele (p=0.011) in the affected subjects with hypercholesterolaemia or hypertension. Similarly, blood pressure and triglyceride levels were significantly lower and HDL-cholesterol levels significantly higher in the subjects with the CT genotype compared to those with the CC genotype (p<0.05). However, the G-75A genotypes did not appear to influence the lipid or blood pressure levels. The -75A allele frequency was higher in our healthy controls than an equivalent Caucasian population (31.1% vs. 18.3%, p<0.001), whereas the 83T allele frequency was similar between the healthy Chinese and Caucasian groups.

    CONCLUSION: The 83T allele may be associated with a better lipid profile and blood pressure levels in this group of Chinese subjects.

    Original languageEnglish
    Pages (from-to)309-14
    Number of pages6
    JournalInternational Journal of Cardiology
    Volume102
    Issue number2
    DOIs
    Publication statusPublished - 10 Jul 2005

    Keywords

    • Adult
    • Alleles
    • Apolipoprotein A-I
    • Asian Continental Ancestry Group
    • Blood Pressure
    • Cholesterol, HDL
    • DNA
    • Female
    • Gene Frequency
    • Genotype
    • Glycoproteins
    • Hong Kong
    • Humans
    • Hypercholesterolemia
    • Hypertension
    • Male
    • Middle Aged
    • Polymerase Chain Reaction
    • Polymorphism, Restriction Fragment Length

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