Abstract
The development of autoimmune thyroid disease (AITD) is associated with autoantibodies directed against the thyroid stimulating hormone receptor (TSHR). Previous studies have failed to demonstrate a consistent association between the TSHR and AITD, or any of its sub-phenotypes. In the present study, we analysed the linkage disequilibrium (LD) structure encompassing the TSHR, to identify LD 'blocks' and SNPs, which capture the majority of intra-block haplotype diversity. The haplotype tagging SNPs, plus all common SNPs reported in previous studies were genotyped in 1,059 AITD Caucasian cases and 971 Caucasian controls. A haplotype, across two LD blocks, showed association (P
Original language | English |
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Pages (from-to) | 1223-1230 |
Number of pages | 8 |
Journal | European Journal of Human Genetics |
Volume | 13 |
DOIs | |
Publication status | Published - 17 Aug 2005 |
Keywords
- GD
- htSNP
- genetic
- AITD
- Graves
- TSHR