Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

A Dehghan; Q Yang; A Peters; S Basu; JC Bis; AR Rudnicka; M Kavousi; MH Chen; J Baumert; GD Lowe; B McKnight; W Tang; M de Maat; MG Larson; S Eyhermendy; WL McArdle; T Lumley; JS Pankow; A Hofman; JM Massaro; F Rivadeneira; M Kolz; KD Taylor; CM van Duijn; S Kathiresan; T Illig; YS Aulchenko; KA Volcik; AD Johnson; AG Uitterlinden; GH Tofler; C Gieger; Jayne Franklyn; Wellcome Trust Care Control Consortium

doi:10.1161/CIRCGENETICS.108.825224

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

A Dehghan, Q Yang, A Peters, S Basu, JC Bis, AR Rudnicka, M Kavousi, MH Chen, J Baumert, GD Lowe, B McKnight, W Tang, M de Maat, MG Larson, S Eyhermendy, WL McArdle, T Lumley, JS Pankow, A Hofman, JM MassaroF Rivadeneira, M Kolz, KD Taylor, CM van Duijn, S Kathiresan, T Illig, YS Aulchenko, KA Volcik, AD Johnson, AG Uitterlinden, GH Tofler, C Gieger, Jayne Franklyn, Wellcome Trust Care Control Consortium

Birmingham Medical School

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Abstract

BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P

Original language	English
Pages (from-to)	125-33
Number of pages	9
Journal	Circulation: Cardiovascular Genetics
Volume	2
Issue number	2
DOIs	https://doi.org/10.1161/CIRCGENETICS.108.825224
Publication status	Published - 1 Apr 2009

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Dehghan, A., Yang, Q., Peters, A., Basu, S., Bis, JC., Rudnicka, AR., Kavousi, M., Chen, MH., Baumert, J., Lowe, GD., McKnight, B., Tang, W., de Maat, M., Larson, MG., Eyhermendy, S., McArdle, WL., Lumley, T., Pankow, JS., Hofman, A., ... Wellcome Trust Care Control Consortium (2009). Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circulation: Cardiovascular Genetics, 2(2), 125-33. https://doi.org/10.1161/CIRCGENETICS.108.825224

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title = "Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts",

abstract = "BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P",

author = "A Dehghan and Q Yang and A Peters and S Basu and JC Bis and AR Rudnicka and M Kavousi and MH Chen and J Baumert and GD Lowe and B McKnight and W Tang and {de Maat}, M and MG Larson and S Eyhermendy and WL McArdle and T Lumley and JS Pankow and A Hofman and JM Massaro and F Rivadeneira and M Kolz and KD Taylor and {van Duijn}, CM and S Kathiresan and T Illig and YS Aulchenko and KA Volcik and AD Johnson and AG Uitterlinden and GH Tofler and C Gieger and Jayne Franklyn and {Wellcome Trust Care Control Consortium}",

year = "2009",

month = apr,

day = "1",

doi = "10.1161/CIRCGENETICS.108.825224",

language = "English",

volume = "2",

pages = "125--33",

journal = "Circulation: Cardiovascular Genetics",

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publisher = "American Heart Association",

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Dehghan, A, Yang, Q, Peters, A, Basu, S, Bis, JC, Rudnicka, AR, Kavousi, M, Chen, MH, Baumert, J, Lowe, GD, McKnight, B, Tang, W, de Maat, M, Larson, MG, Eyhermendy, S, McArdle, WL, Lumley, T, Pankow, JS, Hofman, A, Massaro, JM, Rivadeneira, F, Kolz, M, Taylor, KD, van Duijn, CM, Kathiresan, S, Illig, T, Aulchenko, YS, Volcik, KA, Johnson, AD, Uitterlinden, AG, Tofler, GH, Gieger, C, Franklyn, J & Wellcome Trust Care Control Consortium 2009, 'Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts', Circulation: Cardiovascular Genetics, vol. 2, no. 2, pp. 125-33. https://doi.org/10.1161/CIRCGENETICS.108.825224

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AU - Dehghan, A

AU - Yang, Q

AU - Peters, A

AU - Basu, S

AU - Bis, JC

AU - Rudnicka, AR

AU - Kavousi, M

AU - Chen, MH

AU - Baumert, J

AU - Lowe, GD

AU - McKnight, B

AU - Tang, W

AU - de Maat, M

AU - Larson, MG

AU - Eyhermendy, S

AU - McArdle, WL

AU - Lumley, T

AU - Pankow, JS

AU - Hofman, A

AU - Massaro, JM

AU - Rivadeneira, F

AU - Kolz, M

AU - Taylor, KD

AU - van Duijn, CM

AU - Kathiresan, S

AU - Illig, T

AU - Aulchenko, YS

AU - Volcik, KA

AU - Johnson, AD

AU - Uitterlinden, AG

AU - Tofler, GH

AU - Gieger, C

AU - Franklyn, Jayne

AU - Wellcome Trust Care Control Consortium

PY - 2009/4/1

Y1 - 2009/4/1

N2 - BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P

AB - BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P

U2 - 10.1161/CIRCGENETICS.108.825224

DO - 10.1161/CIRCGENETICS.108.825224

M3 - Article

C2 - 20031576

SN - 1942-3268

VL - 2

SP - 125

EP - 133

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

IS - 2

ER -

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

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